{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:14:38Z","timestamp":1773047678721,"version":"3.50.1"},"reference-count":58,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heart and Stroke Foundation of Canada"},{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p> Early acclimatization to high altitude is characterized by various respiratory, hematological, and cardiovascular adaptations that serve to restore oxygen delivery to tissue. However, less is understood about renal function and the role of renal oxygen delivery (RDO<jats:sub>2<\/jats:sub>) during high altitude acclimatization. We hypothesized that 1) RDO<jats:sub>2<\/jats:sub> would be reduced after 12 h of high altitude exposure (high altitude day 1) but restored to sea level values after 1 wk (high altitude day 7) and 2) RDO<jats:sub>2<\/jats:sub> would be associated with renal reactivity, an index of acid-base compensation at high altitude. Twenty-four healthy lowlander participants were tested at sea level (344 m, Kelowna, BC, Canada) and on day 1 and day 7 at high altitude (4,330 m, Cerro de Pasco, Peru). Cardiac output, renal blood flow, and arterial and venous blood sampling for renin-angiotensin-aldosterone system hormones and NH<jats:sub>2<\/jats:sub>-terminal pro-B-type natriuretic peptides were collected at each time point. Renal reactivity was calculated as follows: (\u0394arterial bicarbonate)\/(\u0394arterial Pco<jats:sub>2<\/jats:sub>) between sea level and high altitude day 1 and sea level and high altitude day 7. The main findings were that 1) RDO<jats:sub>2<\/jats:sub> was initially decreased at high altitude compared with sea level (\u0394RDO<jats:sub>2<\/jats:sub>: \u221222 \u00b1\u200917%, P &lt; 0.001) but was restored to sea level values on high altitude day 7 (\u0394RDO<jats:sub>2<\/jats:sub>: \u22126\u2009\u00b1\u200914%, P = 0.36). The observed improvements in RDO<jats:sub>2<\/jats:sub> resulted from both changes in renal blood flow (\u0394 from high altitude day 1: +12 \u00b1\u200911%, P = 0.008) and arterial oxygen content (\u0394 from high altitude day 1: +44.8\u2009\u00b1\u200917.7%, P = 0.006) and 2) renal reactivity was positively correlated with RDO<jats:sub>2<\/jats:sub> on high altitude day 7 ( r\u2009=\u20090.70, P &lt; 0.001) but not high altitude day 1 ( r\u2009=\u20090.26, P = 0.29). These findings characterize the temporal responses of renal function during early high altitude acclimatization and the influence of RDO<jats:sub>2<\/jats:sub> in the regulation of acid-base balance. <\/jats:p>","DOI":"10.1152\/ajprenal.00372.2020","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T12:10:02Z","timestamp":1601467802000},"page":"F1081-F1089","source":"Crossref","is-referenced-by-count":10,"title":["Global REACH 2018: renal oxygen delivery is maintained during early acclimatization to 4,330 m"],"prefix":"10.1152","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0557-847X","authenticated-orcid":false,"given":"Andrew R.","family":"Steele","sequence":"first","affiliation":[{"name":"Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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