{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:55:59Z","timestamp":1778691359395,"version":"3.51.4"},"reference-count":46,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>The effect of angiotensin-converting enzyme inhibition on function and structure of the aorta was studied in the Lewis polycystic kidney (LPK) rat model of cystic renal disease and Lewis controls. Pulse-wave velocity (PWV) was recorded under urethane anesthesia (1.3 g\/kg ip) in mixed-sex animals aged 6 and 12 wk and in 12-wk-old animals treated with perindopril (3 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>po) from age 6\u201312 wk. Tail-cuff systolic pressures were recorded over the treatment period. After PWV measurements, animals were euthanized and the aorta was removed for histomorphological and calcium analysis. Hypertension in LPK at 6 and 12 wk was associated with a shift of the PWV curve upward and to the right, indicating a decrease in aortic compliance, which was significantly reduced by perindopril. LPK demonstrated greater aortic calcification (6 wk: 123 \u00b1 19 vs. 65 \u00b1 7 and 12 wk: 406 \u00b1 6 vs. 67 \u00b1 6 \u03bcmol\/g, P &lt; 0.001, LPK vs. Lewis, respectively). This was reduced by treatment with perindopril (172 \u00b1 48 \u03bcmol\/g, 12 wk LPK P &lt; 0.001). Medial cross-sectional area and elastic modulus\/wall stress of the aorta were greater in LPK vs. Lewis control animals at 6 and 12 wk of age and showed an age-related increase that was prevented by treatment with perindopril ( P &lt; 0.001). Perindopril also ameliorated the degradation of elastin, increase in collagen content, and medial elastocalcinosis seen in 12-wk LPK. Overall, perindopril improved the structural and functional indices of aortic stiffness in the LPK rats, demonstrating a capacity for angiotensin-converting enzyme inhibition to limit vascular remodeling in chronic kidney disease.<\/jats:p>","DOI":"10.1152\/ajprenal.00393.2011","type":"journal-article","created":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T01:39:26Z","timestamp":1314236366000},"page":"F959-F966","source":"Crossref","is-referenced-by-count":29,"title":["Angiotensin-converting enzyme inhibitor limits pulse-wave velocity and aortic calcification in a rat model of cystic renal disease"],"prefix":"10.1152","volume":"301","author":[{"given":"Keith","family":"Ng","sequence":"first","affiliation":[{"name":"Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara M.","family":"Hildreth","sequence":"additional","affiliation":[{"name":"Australian School of Advanced 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