{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:05Z","timestamp":1790517485089,"version":"4.1.0"},"reference-count":44,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p> Chronic pelvic pain (CPP) disorders frequently overlap. We have demonstrated that acute and chronic colonic irritation can lead to neurogenic cystitis. We hypothesize that acute colonic irritation can sensitize urinary bladder afferents to mechanical and chemical stimuli. Single-unit afferent activity was recorded from fine filaments of the pelvic nerve in urethane-anesthetized Sprague-Dawley female rats before and 1 h after intracolonic administration of trinitrobenzenesulfonic acid (TNBS). Only spontaneously active afferents with receptive fields in the bladder and conduction velocities &lt;2.5 m\/s (unmyelinated C-fibers) were studied. Mechanical sensitivity was tested by bladder distension (BD) during saline infusion, whereas chemical sensitivity was tested with intravesical capsaicin, bradykinin, or substance P. Colonic irritation increased the resting firing rate of bladder afferents twofold (1.0 \u00b1 0.2 vs. 0.49 \u00b1 0.2 impulses\/s, P &lt; 0.05). Moreover, at low-pressure BDs (10\u201320 mmHg), a greater percentage of afferents exhibited increased activity following TNBS (73 vs. 27%, P &lt; 0.05). Although the magnitude of the afferent response to BD was unchanged at low pressures, the response was greatly enhanced at pressures 30 mmHg and above (2.36 \u00b1 0.56 vs. 8.55 \u00b1 0.73 impulses\/s, P &lt; 0.05). Responses to capsaicin, bradykinin, and substance P were also significantly enhanced following TNBS, and all responses were blocked by bladder denervation. In rats, colonic irritation sensitizes urinary bladder afferents to noxious mechanical and chemical stimuli. Interruption of the neural input to the bladder minimized this effect, suggesting a local afferent pathway from the colon. Thus, the overlap of CPP disorders may be a consequence of pelvic afferent cross-sensitization. <\/jats:p>","DOI":"10.1152\/ajprenal.00395.2005","type":"journal-article","created":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T01:34:52Z","timestamp":1136943292000},"page":"F1478-F1487","source":"Crossref","is-referenced-by-count":118,"title":["Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization"],"prefix":"10.1152","volume":"290","author":[{"given":"Elena E.","family":"Ustinova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew O.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Pezzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Alagiri M, Chottiner S, Ratner V, Slade D, and Hanno PM. Interstitial cystitis: unexplained associations with other chronic disease and pain syndromes. Urology 49s: 52\u201357, 1997."},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1995.269.1.G119"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580280"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07181.1997"},{"key":"R5","unstructured":"Christianson JA, Liang R, Davis BM, Fraser MO, and Pezzone MA. Retrograde labeling of urinary bladder and distal colonic afferents: a potential role of dichotomizing afferents in the overlap of chronic pelvic pain disorders. Gastroenterology 126: A115, 2004."},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90125-9"},{"key":"R7","unstructured":"De Groat WC and Booth AM. Neural control of penile erection. In: The Autonomic Nervous System, Vol. 3, Nervous Control of the Urogenital System, edited by Maggi CA. London: Harwood, 1993, p. 467\u2013524."},{"key":"R8","unstructured":"De Groat WC, Booth AM, and Yoshimura N. Neurophysiology of micturition and its modification in animal models of human disease. In: The Autonomic Nervous System, Vol. 3, Nervous Control of the Urogenital System, edited by Maggi CA. London: Harwood, 1993, p. 227\u2013290."},{"key":"R9","unstructured":"De Groat WC, Kawatani M, Houston MB, Rutigliano M, and Erdman S. Identification of neuropeptides in afferent pathways to the pelvic viscera of the cat. In: Organization of the Autonomic Nervous System: Central and Peripheral Mechanisms (Neurology and Neurobiology), Volume 31, edited by Ciriello J, Calaresu F, Renaud L, and Polosa C. New York: A. R. Liss, 1987, p. 81\u201390."},{"key":"R10","doi-asserted-by":"crossref","unstructured":"De Groat WC, Nadelhaft I, Milne RJ, Booth AM, Morgan C, and Thor K. Organization of the sacral parasympathetic reflex pathways to the urinary bladder and large intestine. J Auton Nerv Syst 3: 339\u2013350, 1981.","DOI":"10.1016\/0165-1838(81)90059-X"},{"key":"R11","unstructured":"De Groat WC, Roppolo JR, Yoshimura N, and Sugaya K. Neural control of the urinary bladder and colon. In: Proceedings of the 2nd International Symposium of Brain-Gut Interactions, edited by Tache Y, Wingate D, and Burks T. Boca Raton, FL: CRC, 1993, p. 167\u2013190."},{"key":"R12","unstructured":"De Groat WC and Steers WD. Neuroanatomy and neurophysiology of penile erection. In: Contemporary Management of Impotence and Infertility, edited by Tanagho EA, Lue TF, and McClure RD. Baltimore, MD: Williams and Wilkins, 1988, p. 3\u201327."},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/56.2.149"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)02993-4"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00575-1"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021604"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014021"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.6.G834"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.3.1108"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018117"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(90)90108-U"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-10016.1998"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903190411"},{"key":"R24","unstructured":"Kock NG and Pompeius R. Inhibition of vesical motor activity induced by anal stimulation. Acta Chir Scand 126: 244\u2013250, 1963."},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902030411"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200412030-00008"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00458-0"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014019"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092140416"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00406.2001"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(89)80079-4"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000169258.31345.5d"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.008"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536698"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200403010-00017"},{"key":"R37","unstructured":"Ruch TC. Pathophysiology of pain. In: Physiology and Biophysics: The Brain and Neural Function, edited by Ruch TC and Patton HD. Philadelphia: Saunders, 1979, vol. I, p. 272\u2013324."},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.4.1924"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/71.2.184"},{"key":"R40","unstructured":"Sundin T, Carlsson CA, and Kock NG. Detrusor inhibition induced from mechanical stimulation of the anal region and from electrical stimulation of pudendal nerve afferents. Investig Urol (Berl) 11: 374\u2013377, 1974."},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.01.039"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1007\/s003450100201"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.1.37"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.112904"},{"key":"R45","unstructured":"Zondervan KT, Yudkin PL, Vessey MP, Jenkinson CP, Dawes MG, Barlow DH, and Kennedy SH. The community prevalence of chronic pelvic pain in women and associated illness behavior. Br J Gen Pract 51: 541\u2013547, 2001."}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00395.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:14:00Z","timestamp":1567984440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00395.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1152\/ajprenal.00395.2005"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00395.2005","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}