{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:36:27Z","timestamp":1747190187817,"version":"3.40.5"},"reference-count":61,"publisher":"American Physiological Society","issue":"4","funder":[{"name":"Hungarian National Research, Development and Innovation Office","award":["K-101775"],"award-info":[{"award-number":["K-101775"]}]},{"name":"Hungarian National Research, Development and Innovation Office","award":["K-112964"],"award-info":[{"award-number":["K-112964"]}]},{"name":"Hungarian National Research, Development and Innovation Office","award":["K-125174"],"award-info":[{"award-number":["K-125174"]}]},{"name":"Hungarian National Research, Development and Innovation Office","award":["K-135683"],"award-info":[{"award-number":["K-135683"]}]},{"name":"Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the Molecular Biology thematic program of the Semmelweis University","award":["EFOP-3.6.3-VEKOP-16-2017-00009"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00009"]}]},{"name":"Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the Molecular Biology thematic program of the Semmelweis University","award":["&#x00DA","NKP-19-3-I-SE-107"],"award-info":[{"award-number":["&#x00DA","NKP-19-3-I-SE-107"]}]},{"name":"Hungarian National Research, Development and Innovation Office","award":["PD-132581"],"award-info":[{"award-number":["PD-132581"]}]},{"name":"Hungarian National Research, Development and Innovation Office","award":["NVKP_16-1-2016-0042"],"award-info":[{"award-number":["NVKP_16-1-2016-0042"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p> Voiding disorders affect millions of people worldwide. Inflammation can impair urinary bladder functions and contribute to the development of detrusor overactivity. The effects and signal transduction of inflammatory lipid mediator isoprostanes were studied in human and murine urinary bladders ex vivo. We found that isoprostanes evoke contraction, an effect mediated by thromboxane prostanoid receptors. The G<jats:sub>12\/13<\/jats:sub>-Rho-Rho kinase signaling pathway plays a significant role in mediating the contraction and therefore may be a potential therapeutic target. <\/jats:p>","DOI":"10.1152\/ajprenal.00400.2020","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T11:24:20Z","timestamp":1611573860000},"page":"F537-F547","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Isoprostanes evoke contraction of the murine and human detrusor muscle via activation of the thromboxane prostanoid TP receptor and Rho kinase"],"prefix":"10.1152","volume":"320","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-2343","authenticated-orcid":false,"given":"P\u00e9ter J\u00f3zsef","family":"Moln\u00e1r","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Department of Urology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-8411","authenticated-orcid":false,"given":"B\u00e1lint","family":"D\u00e9r","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0939-4416","authenticated-orcid":false,"given":"Kinga","family":"Borsodi","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-6860","authenticated-orcid":false,"given":"Helga","family":"Balla","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Borb\u00e1s","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Ruisanchez","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-8489","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Kenessey","sequence":"additional","affiliation":[{"name":"2nd Department of Pathology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-4892","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Urology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-2175","authenticated-orcid":false,"given":"Attila","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Department of Urology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-1083","authenticated-orcid":false,"given":"Attila","family":"Majoros","sequence":"additional","affiliation":[{"name":"Department of Urology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-4919","authenticated-orcid":false,"given":"P\u00e9ter","family":"Nyir\u00e1dy","sequence":"additional","affiliation":[{"name":"Department of Urology, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8676-6805","authenticated-orcid":false,"given":"Stefan","family":"Offermanns","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-0359","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Beny\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14063"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000447205"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.09.012"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-31696-5.00024-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.01.001"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.33"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-020-00619-0"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67397-X"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.11.070"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701903"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.14087"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700047200"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(97)00005-1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/10715760310001646895"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.13075\/ijomeh.1896.00596"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2017-0388"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.04.016"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12677"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000161411.01208.83"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.2.8564103"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702433"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nm943"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nm1101-1236"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.22.4324"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00106.2019"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nm1666"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01274.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000127438.39744.07"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1139\/y82-139"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.03.022"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.11.030"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.10.052"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050237"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1994.tb07447.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02243-4"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.038"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2018.59.4.252"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2015.43"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07310.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23452"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.10.57"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8267234"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.06.001"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.12.031"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12577"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67951-7"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-007-0529-z"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09r12fm"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.05.042"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(2000)19:1<43::AID-NAU6>3.0.CO;2-C"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.17221\/7657-VETMED"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-16499-6_2"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.24.2833"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703522"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1159\/000092049"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00340.2005"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00025.2003"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0364"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2017-0071"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.027"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900961RR"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00400.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T08:43:01Z","timestamp":1624437781000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00400.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["10.1152\/ajprenal.00400.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00400.2020","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"type":"print","value":"1931-857X"},{"type":"electronic","value":"1522-1466"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"2020-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}