{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:26:36Z","timestamp":1792196796770,"version":"4.4.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>We have isolated and characterized a novel human and rat organic anion transporter subtype, OATP-D. The isolated cDNA from human brain encodes a polypeptide of 710 amino acids ( M<jats:sub>r<\/jats:sub>76,534) with 12 predicted transmembrane domains. The rat clone encodes 710 amino acids ( M<jats:sub>r<\/jats:sub>76,821) with 97.6% amino acid sequence homology with human OATP-D. Human and rat OATP-D have moderate amino acid sequence homology with LST-1\/rlst-1, the rat oatp family, the prostaglandin transporter, and moat1\/MOAT1\/KIAA0880\/OATP-B. Phylogenetic tree analysis revealed that OATP-D is branched in a different position from all known organic anion transporters. OATP-D transports prostaglandin E<jats:sub>1<\/jats:sub>( K<jats:sub>m<\/jats:sub>48.5 nM), prostaglandin E<jats:sub>2<\/jats:sub>( K<jats:sub>m<\/jats:sub>55.5 nM), and prostaglandin F<jats:sub>2\u03b1<\/jats:sub>, suggesting that, functionally, OATP-D encodes a protein that has similar characteristics to those of the prostaglandin transporter. Rat OATP-D also transports prostaglandins. The expression pattern of OATP-D mRNA was abundant mainly in the heart, testis, brain, and some cancer cells. Immunohistochemical analysis further revealed that rat OATP-D is widely expressed in the vascular, renal, and reproductive system at the protein level. These results suggest that OATP-D plays an important role in translocating prostaglandins in specialized tissues and cells.<\/jats:p>","DOI":"10.1152\/ajprenal.00402.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:39:50Z","timestamp":1425415190000},"page":"F1188-F1197","source":"Crossref","is-referenced-by-count":71,"title":["Molecular characterization of human and rat organic anion transporter OATP-D"],"prefix":"10.1152","volume":"285","author":[{"given":"Hisanobu","family":"Adachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Mizutamari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Tanemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Onogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Toyohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitoshi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Tokui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Unno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tooru","family":"Shimosegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiki","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadayoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.35.22395"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.24.17159"},{"key":"REF3","doi-asserted-by":"crossref","unstructured":"Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, and Nakanishi S.Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate\/Ca2+signal transduction.J Biol Chem267: 13361\u201313368, 1992.","DOI":"10.1016\/S0021-9258(18)42219-3"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(02)00599-4"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24804"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(76)90067-8"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(81)90203-3"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.1.F12"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1996.270.3.F485"},{"key":"REF10","unstructured":"Campbell WBand Halshka PV.Lipid-derived autacoids: eicosanoids, and platelet-activating factor. 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