{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:28:18Z","timestamp":1778711298902,"version":"3.51.4"},"reference-count":18,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p> Experiments were performed to determine the effect of amniotic fluid dilution on the rate of intramembranous absorption. Seven fetal sheep at 118 days gestation were instrumented with a shunt between the trachea and esophagus and arterial and venous vascular catheters. In addition, the urachus of the fetal bladder was ligated, and a catheter was placed in the bladder. Ligation of the urachus does not interfere with urine flow into the amnion. After 5 days of recovery, fetuses were randomly assigned to one of two protocols; all fetuses completed both protocols. In the fetuses in the control period, continuous urine flow measurement was begun. In the fetuses assigned to the isovolumic dilution protocol, continuous urine flow measurement was also begun and, in addition, amniotic fluid was continually exchanged with lactated Ringer solution on an isovolumic basis. After 3\u20134 days, fetal blood pressures and amniotic fluid volumes were determined. Amniotic fluid volumes were determined by drainage. Each fetus was then assigned to the remaining protocol. The presence of the tracheal-esophageal shunt and the ligation of the urachus allowed the rate of intramembranous absorption to be calculated. Isovolumic exchange showed no effect on fetal vascular pressures, blood-gas values, or urine production. We could demonstrate no effect of isovolumic dilution of amniotic fluid on its volume. However, we were able to demonstrate an inverse relationship between amniotic fluid volume and intramembranous absorption ( P &lt; 0.02). <\/jats:p>","DOI":"10.1152\/ajprenal.00407.2004","type":"journal-article","created":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T17:18:29Z","timestamp":1112980709000},"page":"F964-F968","source":"Crossref","is-referenced-by-count":16,"title":["Intramembranous absorption rate is unaffected by changes in amniotic fluid composition"],"prefix":"10.1152","volume":"288","author":[{"given":"D.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hohimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Faber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Giraud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199706000-00005"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90094-9"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.266.4.R1345"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.6.2401"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1990.259.4.R745"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.1.R236"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00746.2001"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90005-C"},{"key":"R9","unstructured":"GilbertW and Brace R. The missing link in amniotic fluid volume regulation: intramembranous absorption. Obstet Gynecol74 : 748\u2013753, 1989."},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90576-D"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91768-6"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.119806"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.104226"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.112971"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199706000-00011"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00494-0"},{"key":"R17","unstructured":"WintourEM, Barnes A, Brown EH, Hardy KJ, Horacek I, McDougall JG, and Scoggins BA. Regulation of amniotic fluid volume and composition in the ovine fetus. 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