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Moreover, increased dietary K+<\/jats:sup>intake inhibited, whereas decreased dietary K+<\/jats:sup>intake stimulated, the basolateral potassium channel (a Kir4.1\/Kir5.1 heterotetramer) in the DCT. The alteration of basolateral potassium conductance is essential for the effect of dietary K+<\/jats:sup>intake on NCC because deletion of Kir4.1 in the DCT abolished the effect of dietary K+<\/jats:sup>intake on NCC. Since potassium intake-mediated regulation of NCC plays a key role in regulating renal K+<\/jats:sup>excretion and potassium homeostasis, the deletion of Kir4.1 caused severe hypokalemia and metabolic alkalosis under control conditions and even during increased dietary K+<\/jats:sup>intake. Finally, recent studies have suggested that the angiotensin II type 2 receptor (AT2R) and bradykinin-B2 receptor (BK2R) are involved in mediating the effect of high dietary K+<\/jats:sup>intake on Kir4.1\/Kir5.1 in the DCT.<\/jats:p>","DOI":"10.1152\/ajprenal.00412.2018","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T12:48:43Z","timestamp":1547038123000},"page":"F582-F586","source":"Crossref","is-referenced-by-count":65,"title":["Kir4.1\/Kir5.1 in the DCT plays a role in the regulation of renal K+<\/sup>excretion"],"prefix":"10.1152","volume":"316","author":[{"given":"Xiao-Tong","family":"Su","sequence":"first","affiliation":[{"name":"Department of Pharmacology, New York Medical College, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-265X","authenticated-orcid":false,"given":"David H.","family":"Ellison","sequence":"additional","affiliation":[{"name":"Division of Nephrology 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