{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:39:32Z","timestamp":1788287972717,"version":"build-2803163510"},"reference-count":52,"publisher":"American Physiological Society","issue":"6","funder":[{"name":"National Institute of Health","award":["R01 HD38679"],"award-info":[{"award-number":["R01 HD38679"]}]},{"name":"the Rehabilitation Research and Development Service of the Veterans Affairs","award":["A1262-R"],"award-info":[{"award-number":["A1262-R"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["No. 81670695"],"award-info":[{"award-number":["No. 81670695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001466","name":"American Urological Association Foundation (AUA Foundation)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001466","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011240","name":"Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011240","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:p>The pudendal nerve can be injured during vaginal delivery of children, and slowed pudendal nerve regeneration has been correlated with development of stress urinary incontinence (SUI). Simultaneous injury to the pudendal nerve and its target muscle, the external urethral sphincter (EUS), during delivery likely leads to slowed neuroregeneration. The goal of this study was to determine if repeat electrical stimulation of the pudendal nerve improves SUI recovery and promotes neuroregeneration in a dual muscle and nerve injury rat model of SUI. Rats received electrical stimulation or sham stimulation of the pudendal nerve twice weekly for up to 2 wk after injury. A separate cohort of rats received sham injury and sham stimulation. Expression of brain-derived neurotrophic factor (BDNF) and \u03b2<jats:sub>II<\/jats:sub>-tubulin expression in Onuf\u2019s nucleus were measured 2, 7, and 14 days after injury. Urodynamics, leak point pressure (LPP), and EUS electromyography (EMG) were recorded 14 days after injury. Electrical stimulation significantly increased expression of BDNF at all time points and \u03b2<jats:sub>II<\/jats:sub>-tubulin 1 and 2 wk after injury. Two weeks after injury, LPP and EUS EMG during voiding and LPP testing were significantly decreased compared with sham-injured animals. Electrical stimulation significantly increased EUS activity during voiding, although LPP did not fully recover. Repeat pudendal nerve stimulation promotes neuromuscular continence mechanism recovery possibly via a neuroregenerative response through BDNF upregulation in the pudendal motoneurons in this model of SUI. Electrical stimulation of the pudendal nerve may therefore improve recovery after childbirth and ameliorate symptoms of SUI by promoting neuroregeneration after injury.<\/jats:p>","DOI":"10.1152\/ajprenal.00431.2017","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T11:02:18Z","timestamp":1534935738000},"page":"F1555-F1564","source":"Crossref","is-referenced-by-count":31,"title":["Electrical stimulation of the pudendal nerve promotes neuroregeneration and functional recovery from stress urinary incontinence in a rat model"],"prefix":"10.1152","volume":"315","author":[{"given":"Hai-Hong","family":"Jiang","sequence":"first","affiliation":[{"name":"Neuro-Urology Center, Department of Urology and Andrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, 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