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Pseudohypoaldosteronism type II (PHAII) or familial hyperkalemic hypertension (FHHt) is a rare, autosomal dominant syndrome characterized by hypertension, hyperkalemia, metabolic acidosis, elevated or low aldosterone levels, and decreased plasma renin activity. PHAII is caused by mutations in the WNK isoforms (with no lysine kinase), which regulate the Na-Cl and Na-K-Cl cotransporters (NCC and NKCC2, respectively) and the renal outer medullary potassium (ROMK) channel in the DCT. This review focuses on new candidate genes such as KLHL3 and Cullin3, which are instrumental to unraveling novel signal transductions pathways involving NCC, to better understand the cause of PHAII along with the molecular mechanisms governing the pathophysiology of PHAII and its clinical manifestations.<\/jats:p>","DOI":"10.1152\/ajprenal.00440.2013","type":"journal-article","created":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T16:01:17Z","timestamp":1381420877000},"page":"F1513-F1520","source":"Crossref","is-referenced-by-count":54,"title":["A molecular update on pseudohypoaldosteronism type II"],"prefix":"10.1152","volume":"305","author":[{"given":"Ganesh","family":"Pathare","sequence":"first","affiliation":[{"name":"Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost G. 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