{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:29:54Z","timestamp":1790198994526,"version":"4.1.0"},"reference-count":61,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100009974","name":"Cardinal Tien Hospital","doi-asserted-by":"publisher","award":["108-CTH-FJU-02"],"award-info":[{"award-number":["108-CTH-FJU-02"]}],"id":[{"id":"10.13039\/501100009974","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["103-FEMH-FJU-02"],"award-info":[{"award-number":["103-FEMH-FJU-02"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-2MOST314-B-030-004-MY3"],"award-info":[{"award-number":["108-2MOST314-B-030-004-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p> Ionotropic N-methyl-d-aspartate receptors (NMDARs) are not only present in the nervous system but also expressed in the kidney. Overstimulation of renal NMDARs leads to oxidative stress via the signal pathway of calcium\/protein kinase C\/NADPH oxidase in d-serine-mediated tubular cell damage. Intervention of NMDAR blockade may prevent acute renal injury caused by d-serine. <\/jats:p>","DOI":"10.1152\/ajprenal.00461.2020","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T10:51:37Z","timestamp":1616410297000},"page":"F799-F813","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>N<\/i>-methyl-<scp>d<\/scp>-aspartate receptor hyperfunction contributes to <scp>d<\/scp>-serine-mediated renal insufficiency"],"prefix":"10.1152","volume":"320","author":[{"given":"Yi-Shiou","family":"Tseng","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hou","family":"Liao","sequence":"additional","affiliation":[{"name":"Divisions of Urology, Department of Surgery, Cardinal Tien Hospital, New Taipei, Taiwan"},{"name":"School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-5203","authenticated-orcid":false,"given":"Ming-Chieh","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000013293.11876.4e"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00718.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132204"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.114116"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00169.2003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00481.2007"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/biom10071051"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90391.2008"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251915"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201812032"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512927200"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.07.025"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13409"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00441.2006"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.032"},{"key":"B16","first-page":"269","volume":"77","author":"Ganote CE","year":"1974","journal-title":"Am J Pathol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1021\/tx0500326"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.08.008"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11049-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1597-12.2012"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V9101767"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.10.008"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/ncb754"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221039"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0414-0"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(02)00704-2"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-007-1631-2"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0895"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00051.2009"},{"key":"B30","first-page":"658","volume":"99","author":"Carone FA","year":"1975","journal-title":"Arch Pathol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.276.6.F857"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.194713"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9053-6"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2010.214"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.031"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318265c4d8"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.1999.00058.x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.01.032"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00673.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101753"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00390.x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00301"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb46267.x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00537"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/131737"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvz025"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0289-7"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2017.00088"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.09.062"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00064-X"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90093-6"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2011.27.3.259"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv028"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00428.2010"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00017.2010"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.153"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029930"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.12.092"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.2131\/jts.36.507"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/path.4764"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00461.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T08:50:17Z","timestamp":1624438217000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00461.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["10.1152\/ajprenal.00461.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00461.2020","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"2020-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}