{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:04:32Z","timestamp":1790017472868,"version":"4.0.1"},"reference-count":98,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>Polyuria, hypernatremia, and hypovolemia are the major clinical signs of inherited nephrogenic diabetes insipidus (NDI). Hypernatremia is commonly considered a secondary sign caused by the net loss of water due to insufficient insertion of aquaporin-2 water channels into the apical membrane of the collecting duct cells. In the present study, we employed transcriptome-wide expression analysis to study gene expression in V2 vasopressin receptor (Avpr2)-deficient mice, an animal model for X-linked NDI. Gene expression changes in NDI mice indicate increased proximal tubular sodium reabsorption. Expression of several key genes including Na<jats:sup>+<\/jats:sup>-K<jats:sup>+<\/jats:sup>-ATPase and carbonic anhydrases was increased at the mRNA levels and accompanied by enhanced enzyme activities. In addition, altered expression was also observed for components of the eicosanoid and thyroid hormone pathways, including cyclooxygenases and deiodinases, in both kidney and hypothalamus. These effects are likely to contribute to the clinical NDI phenotype. Finally, our data highlight the involvement of the renin-angiotensin-aldosterone system in NDI pathophysiology and provide clues to explain the effectiveness of diuretics and indomethacin in the treatment of NDI.<\/jats:p>","DOI":"10.1152\/ajprenal.00465.2007","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T00:24:12Z","timestamp":1219278252000},"page":"F1177-F1190","source":"Crossref","is-referenced-by-count":18,"title":["V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis"],"prefix":"10.1152","volume":"295","author":[{"given":"Nicole","family":"Schliebe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Strotmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Busse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Mitschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Biebermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Schomburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"K\u00f6hrle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"B\u00e4r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"R\u00f6mpler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Wess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Sch\u00f6neberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Sangkuhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1995.1009"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Adachi M, Kitamura K, Miyoshi T, Narikiyo T, Iwashita K, Shiraishi N, Nonoguchi H, Tomita K.Activation of epithelial sodium channels by prostasin inXenopusoocytes.J Am Soc Nephrol12: 1114\u20131121, 2001.","DOI":"10.1681\/ASN.V1261114"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00556.2004"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979105"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00591097"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112858"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.629bm.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.05.002"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00061.2006"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.579"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-4-1716"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00054.2002"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.4.2163"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00605.2005"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.276.1.C102"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.04.015"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542718"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Chan JS, Ming M, Nie ZR, Sikstrom R, Lachance S, Carriere S.Hormonal regulation of expression of the angiotensinogen gene in cultured opossum kidney proximal tubular cells.J Am Soc Nephrol2: 1516\u20131522, 1992.","DOI":"10.1093\/ajh\/6.2.141"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32821f6060"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00038.2002"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1038\/183891a0"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Dies F, Suarez MA, Rivera A.Treatment of diabetes insipidus with orally administered compounds.Clin Pharmacol Ther12: 602\u2013611, 1963.","DOI":"10.1002\/cpt196345602"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105044200"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.4.F607"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg624"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06019"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.0021.2001"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(02)00377-9"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005040371"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.20.7917"},{"key":"R31","doi-asserted-by":"crossref","unstructured":"Geppert M, Archer BT 3rd, Sudhof TC 2nd.Synaptotagmin, a novel differentially distributed form of synaptotagmin.J Biol Chem266: 13548\u201313552, 1991.","DOI":"10.1016\/S0021-9258(18)92733-X"},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Gick GG, Ismail-Beigi F, Edelman IS.Thyroidal regulation of rat renal and hepatic Na,K-ATPase gene expression.J Biol Chem263: 16610\u201316618, 1988.","DOI":"10.1016\/S0021-9258(18)37434-9"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Harris RC, Breyer MD.Physiological regulation of cyclooxygenase-2 in the kidney.Am J Physiol Renal Physiol281: F1\u2013F11, 2001.","DOI":"10.1152\/ajprenal.2001.281.1.F1"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507450103"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.68.349"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(74)90292-2"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj102"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.42"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000143476.93376.04"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00176.2003"},{"key":"R42","unstructured":"Knepper MA, Nielsen S, Chou CL, DiGiovanni SR.Mechanism of vasopressin action in the renal collecting duct.Semin Nephrol14: 302\u2013321, 1994."},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01079.x"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1590009"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.272.2.E227"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00114.2004"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.3.F552"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1159\/000077593"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.5.8477661"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00021.2003"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405497200"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00376.2002"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00143-4"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1735416100"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00661-3"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117863"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00207.2004"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.959"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1042\/bj3050081"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1038\/ng1180"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.15.4687"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213229"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00158.2005"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1038\/364341a0"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1195-0"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1126\/science.3453112"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.4.1043"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002020"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90340-1"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00305.2004"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071516798"},{"key":"R73","unstructured":"Rozen S, Skaletsky HJ.Primer3 on the WWW for General Users and for Biologist Programmers.Totowa, NJ: Humana, 2000."},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh105"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000211"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.06.041"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1038\/nn1614"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.266.5.R1591"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00857.x"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.0092.2001"},{"key":"R81","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508658200"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-2057-8"},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1038\/35036318"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1998.00282.x"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1021\/bi00007a015"},{"key":"R88","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00116.2003"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.1080\/ann.34.3.192.200"},{"key":"R90","doi-asserted-by":"publisher","DOI":"10.1159\/000070246"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2005.03.006"},{"key":"R92","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000187474.47805.30"},{"key":"R93","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0303329101"},{"key":"R94","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90139-2"},{"key":"R95","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.31"},{"key":"R96","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00147.2002"},{"key":"R97","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00494.2005"},{"key":"R98","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.4.Ha1"},{"key":"R99","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9154"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00465.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T07:05:07Z","timestamp":1631689507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00465.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":98,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1152\/ajprenal.00465.2007"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00465.2007","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}