{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:52:05Z","timestamp":1776109925074,"version":"3.50.1"},"reference-count":33,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100008476","name":"UC | University of California, Irvine","doi-asserted-by":"publisher","award":["R21AG093287"],"award-info":[{"award-number":["R21AG093287"]}],"id":[{"id":"10.13039\/100008476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008476","name":"UC | University of California, Irvine","doi-asserted-by":"publisher","award":["R01DK131211"],"award-info":[{"award-number":["R01DK131211"]}],"id":[{"id":"10.13039\/100008476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>This study provides the first comprehensive quantitative characterization of adrenergic and muscarinic receptor distribution throughout the porcine ureter using qPCR and immunohistochemistry. Novel findings include the first quantification of all \u03b2-adrenoceptor subtypes, revealing \u03b2-2 dominance (74% of \u03b2-receptors, 54% of total transcripts), and detection of M1 muscarinic receptor mRNA. \u03b1-1a\/1d codominance mirrors human ureters. Predominant urothelial receptor localization suggests epithelial smooth muscle signaling. These data strengthen the understanding of porcine ureteral physiology for clinical and translational studies.<\/jats:p>","DOI":"10.1152\/ajprenal.00466.2025","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T16:40:48Z","timestamp":1774370448000},"page":"F522-F529","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of \u03b1, \u03b2, and muscarinic receptor distribution in porcine ureters: a translational model for pharmacological ureteral dilation"],"prefix":"10.1152","volume":"330","author":[{"given":"Victor","family":"Pham","sequence":"first","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison","family":"Rivero","sequence":"additional","affiliation":[{"name":"University of California","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet T.","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"University of California","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caila","family":"Ruiz-May","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Grinnell College","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9412-2271","authenticated-orcid":false,"given":"Gokhan","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Gao","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengbo","family":"Jiang","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Patel","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Landman","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Mauney","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]},{"name":"University of California","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-7457","authenticated-orcid":false,"given":"Ralph V.","family":"Clayman","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7833-1481","authenticated-orcid":false,"given":"Yi Xi","family":"Wu","sequence":"additional","affiliation":[{"name":"University of California, Irvine","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.20200526"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.197"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1089\/end.2018.0603"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0482-4"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1089\/end.2010.0400"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59040744"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02142-0"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2017.83548"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2336-1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.09.173"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01812.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-007-0118-0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20097"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12093"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67200-X"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1089\/end.2006.20.939"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1590\/ACB351208"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2019.106661"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000133557.39515.b6"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.1995.tb00401.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-007-2043-2"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1540\/jsmr.42.103"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1510-8"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2022.07.004"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1124\/mol.115.098129"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b02811"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(05)66049-1"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199608)245:4<645::AID-AR4>3.0.CO;2-N"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318180e4c9"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-JAALAS-22-000083"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5021"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.11.012"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1993.tb00206.x"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00466.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:22:44Z","timestamp":1776104564000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00466.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajprenal.00466.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00466.2025","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}