{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:40:50Z","timestamp":1776127250052,"version":"3.50.1"},"reference-count":31,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK51265"],"award-info":[{"award-number":["DK51265"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK95785"],"award-info":[{"award-number":["DK95785"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK62794"],"award-info":[{"award-number":["DK62794"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK7569"],"award-info":[{"award-number":["DK7569"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK114809"],"award-info":[{"award-number":["P30DK114809"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["00507969"],"award-info":[{"award-number":["00507969"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p> Experimental myocardial infarction (MI) protects from subsequent ischemic acute kidney injury but worsens chronic kidney injury. Observed protection from ischemic acute kidney injury after MI was accompanied by chronic kidney hypoxia and increased renal abundance of hypoxia-inducible transcripts. These data support the idea that MI confers protection from renal ischemic injury via chronic renal hypoxia and activation of downstream hypoxia-inducible signaling pathways. <\/jats:p>","DOI":"10.1152\/ajprenal.00476.2020","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T11:15:31Z","timestamp":1612178131000},"page":"F569-F577","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction"],"prefix":"10.1152","volume":"320","author":[{"given":"Andrew S.","family":"Terker","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pablo","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aolei","family":"Niu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sochinweichi","family":"Nwosisi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond C.","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"},{"name":"Vanderbilt Center for Kidney Disease, Nashville, Tennessee"},{"name":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.072"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1017-8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht386"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.03.011"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167166"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.156"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.06.022"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60363"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008181"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3791\/58520"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00279.2012"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00219.2019"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57324"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019050534"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00224.2015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00667.2011"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3762"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(46)90067-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008181"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00532.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.08.037"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013010084"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4189"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122130"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000221"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1159\/000446571"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.12"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69073"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010121249"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103377"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.070"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00476.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T08:43:14Z","timestamp":1624437794000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00476.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["10.1152\/ajprenal.00476.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00476.2020","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"2020-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}