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In female Eln haploinsufficient mice, ovarian hormone depletion elevates systolic blood pressure. Eln haploinsufficiency augments sodium and water reabsorption that is, in part, mediated by sustained activity of the vasopressin V\n                    <jats:sub>2<\/jats:sub>\n                    receptor and is associated with ENaC-dependent blood pressure elevation. These findings implicate abnormal sodium and water handling by the kidney as a contributing mechanism besides arteriopathy as the primary drivers of hypertension resulting from Eln haploinsufficiency.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00485.2025","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:10:18Z","timestamp":1774278618000},"page":"F499-F512","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ovarian hormones moderate systolic hypertension in female\n                    <i>Eln<\/i>\n                    haploinsufficient mice"],"prefix":"10.1152","volume":"330","author":[{"given":"Alethia J.","family":"Dixon","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine","place":["United 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