{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:04:07Z","timestamp":1791842647427,"version":"4.3.4"},"reference-count":42,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>Our findings delineate a sequential NF-\u03baB\/Apaf1\/caspase-9\/autophagy pathway that amplifies tubular inflammation and apoptosis in septic AKI. Targeting this axis may provide a novel therapeutic strategy to preserve tubular integrity, limit inflammation, and improve renal outcomes in patients with sepsis-associated AKI.<\/jats:p>","DOI":"10.1152\/ajprenal.00489.2025","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:10:37Z","timestamp":1772064637000},"page":"F389-F404","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["NF-\u03baB\/Apaf1\/caspase-9 axis suppresses autophagy to drive tubular inflammation and apoptosis in septic acute kidney injury"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5666-1400","authenticated-orcid":false,"given":"Juan","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Xiangya Hospital at Central South University","place":["People\u2019s Republic of China"]},{"name":"The Second Xiangya Hospital of Central South University","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital at Central South University","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Peng","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nongyang","family":"Yan","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital of Central South University","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4680-3200","authenticated-orcid":false,"given":"Zhiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital at Central South University","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00284-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00293-4"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-025-00973-y"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04877-4"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.05.026"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4891"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115924"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000809"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030261"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_11"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.180"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142272"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.033"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015060647"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113050"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13565"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80434-1"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.43"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.519"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep22171"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.02.016"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi8051"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50093"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112615"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.01.006"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015070748"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI121859"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019101060"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.142"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05351-5"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000362"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00750-4"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.03.014"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0545-9"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg8156"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101767"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032821"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00929-x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1405880"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.04.002"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2025.2525668"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402127"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00489.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:12:49Z","timestamp":1774278769000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00489.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1152\/ajprenal.00489.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00489.2025","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}