{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:00:25Z","timestamp":1791126025053,"version":"4.1.0"},"reference-count":70,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p>Diabetes and increased blood pressure (BP) are believed to interact synergistically in the pathogenesis and progression of diabetic nephropathy. The present studies were performed to examine if there were differences in BP load and\/or protective renal autoregulatory capacity between the obese diabetic Zucker fatty \/spontaneously hypertensive heart failure F1 hybrid (ZSF1) ( fa\/ fa<jats:sup>cp<\/jats:sup>) rats and their lean controls. By \u223c26 wk of age, ZSF1 ( n = 13) but not their lean controls ( n = 16) had developed substantial proteinuria (180 \u00b1 19 vs. 16 \u00b1 1.4 mg\/24 h) and glomerulosclerosis (19 \u00b1 2.4 vs. 0.6 \u00b1 0.2%; P &lt; 0.001). However, average ambient systolic BP by radiotelemetry (12\u201326 wk of age) was modestly lower in ZSF1 than in lean controls (130 \u00b1 1.4 vs. 137 \u00b1 1.7 mmHg, P &lt; 0.002), although the 24-h BP power spectra showed a mild increase at frequencies &lt;0.1 Hz in the ZSF1. Autoregulatory capacity under anesthesia in response to step changes in perfusion pressure between 100 and 140 mmHg was similarly well preserved in both ZSF1 and lean controls at 16\u201318 wk of age [autoregulatory indexes (AI) &lt;0.1]. Similarly, differences were not observed for dynamic autoregulation in conscious rats [transfer functions between BP (input) and renal blood flow (output) using chronic Transonic flow probes]. Collectively, these data indicate that the pathogenesis of nephropathy in the ZSF1 model of type 2 diabetic nephropathy is largely independent of differences in systemic BP and\/or its potential renal transmission. However, these data do not exclude the possibility that the diabetic milieu may alter the glomerular capillaries in the ZSF1, such that there is an enhanced local susceptibility to injury with even normal glomerular pressures.<\/jats:p>","DOI":"10.1152\/ajprenal.00511.2006","type":"journal-article","created":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T00:59:32Z","timestamp":1188435572000},"page":"F1605-F1613","source":"Crossref","is-referenced-by-count":49,"title":["Dynamic blood pressure load and nephropathy in the ZSF1 (<i>fa<\/i>\/<i>fa<\/i><sup>cp<\/sup>) model of type 2 diabetes"],"prefix":"10.1152","volume":"293","author":[{"given":"Karen A.","family":"Griffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abu-Naser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Abu-Amarah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Picken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Bidani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00297.2005"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.227"},{"key":"R3","unstructured":"Bakris GL, Williams M, Dworkin L, Elliott WJ, Epstein M, Toto R, Tuttle K, Douglas J, Hsueh W, Sowers J, for the National Kidney Foundation Hypertension, and Diabetes Executive Committees Working Group.Preserving renal function in adults with hypertension and diabetes: a consensus approach.Am J Kidney Dis36: 646\u2013661, 2003."},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.055616"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(73)90243-6"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.265.3.F391"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200201000-00011"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000129170.50448.5f"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00012.2003"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00183.2006"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1987.252.6.F1003"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004110967"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.46.1.223"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200305000-00008"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.261.4.H1292"},{"key":"R16","unstructured":"Christensen K, Parving HH.Autoregulation of glomerular filtration rate in patients with diabetes. In:The Kidney and Hypertension in Diabetes Mellitus(6th Ed.), edited by Mogensen CE. London: Taylor & Francis, 2004, p. 495\u2013514."},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00836.x"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100000"},{"key":"R19","unstructured":"Cortes P, Yee J.Pressure-induced and metabolic alterations in the glomerulus: cytoskeletal changes. In:The Kidney and Hypertension in Diabetes Mellitus(6th Ed.), edited by Mogensen CE. London: Taylor & Francis, 2004, p. 13\u201326."},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00529.2006"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000406"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70217-2"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.264.6.R1254"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00401.2003"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Griffin KA, Picken M, Bidani AK.Method of renal mass reduction is a critical determinant of subsequent hypertension and glomerular injury.J Am Soc Nephrol4: 2023\u20132031, 1994.","DOI":"10.1681\/ASN.V4122023"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Griffin KA, Picken MM, Bidani AK.Deleterious effects on calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys.J Clin Invest96: 798\u2013800, 1995.","DOI":"10.1172\/JCI118125"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00356.x"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780392"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90490-9"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059002702.x"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200001000-00009"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00007.x"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(90)90132-3"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00340.2006"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.1_Suppl.I110"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.47"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.67097.x"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000150857.39919.cb"},{"key":"R40","doi-asserted-by":"crossref","unstructured":"Leehey DJ, Singh AK, Alavi N, Singh R.Role of angiotensin II in diabetic nephropathy.Kidney Int77:S93\u2013S98, 2000.","DOI":"10.1046\/j.1523-1755.2000.07715.x"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00402.2005"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.7.738"},{"key":"R43","unstructured":"Michaelis OE, Patrick DH, Hansen CT, Canary JJ, Werner RM, Carswell N.Insulin-independent diabetes mellitus (type II) spontaneous hypertensive\/NIH-corpulent rat.Am J Pathol123: 398\u2013400, 1986."},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70174-9"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1038\/35008121"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70172-5"},{"key":"R47","unstructured":"Olson JL.Diabetes mellitus. In:Heptinstall's Pathology of the Kidney(5th Ed.), edited by Jennette JC, Olson JL, Schwartz MM, Silva FG. Philadelphia, PA: Lippincott-Raven, 1998, p. 1247\u20131286."},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00123.x"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2002"},{"key":"R50","unstructured":"Peterson RG.The Zucker diabetic fatty rat. In:Animal Models of Diabetes: a Primer, edited by Anders AFS, Elazar S. Amsterdam: Harwood Academic, 2000, p. 109\u2013127."},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1159\/000025912"},{"key":"R52","unstructured":"Proakis JG, Manolakis DG.Digital signal processing. In:Principles, Algorithms, and Applications(3rd Ed.). Upper Saddle River, NJ: Prentice-Hall, 1996."},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00600.x"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411506"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00496.x"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.75.5.844"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.10.1139"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.20.2579"},{"key":"R59","unstructured":"Steffes MW, Mauer SM.Diabetic glomerulopathy in man and experimental animal models. In:International Review of Experimental Pathology. New York: Academic, 1984, p. 147\u2013175."},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00278.x"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-100100882"},{"key":"R62","doi-asserted-by":"crossref","unstructured":"Vora JP, Zimsen SM, Houghton DC, Anderson S.Evolution of metabolic and renal changes in the ZDF\/Drt-fa rat model of type II diabetes.J Am Soc Nephrol7: 113\u2013117, 1996.","DOI":"10.1681\/ASN.V71113"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2328"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90023-8"},{"key":"R65","unstructured":"Wolf G, Ziyadeh FN.Leptin and renal fibrosis. In:Obesity and the Kidney, edited by Wolf G. Basel: Karger, 2006, p. 175\u2013183."},{"key":"R66","unstructured":"Woolson RF.Statistical Methods for the Analysis of Biomedical Data. Wiley Series in Probability and Mathematical Statistics. Philadelphia, PA: Wiley, 1987, p. 314\u2013344."},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.3.728"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112521"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.5963"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00219.x"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00511.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T14:43:35Z","timestamp":1629643415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00511.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1152\/ajprenal.00511.2006"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00511.2006","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}