{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:30:39Z","timestamp":1791502239149,"version":"4.3.4"},"reference-count":39,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs (VA)","doi-asserted-by":"publisher","award":["VA Merit BX002175"],"award-info":[{"award-number":["VA Merit BX002175"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK101841"],"award-info":[{"award-number":["DK101841"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["P30-DK 079337"],"award-info":[{"award-number":["P30-DK 079337"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["T32 DK104717"],"award-info":[{"award-number":["T32 DK104717"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences (NIGMS)","doi-asserted-by":"publisher","award":["K08 GM102695"],"award-info":[{"award-number":["K08 GM102695"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["R01-HL091957"],"award-info":[{"award-number":["R01-HL091957"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["R01-HL107652"],"award-info":[{"award-number":["R01-HL107652"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["K24 HL132105"],"award-info":[{"award-number":["K24 HL132105"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["RO1 HL085188"],"award-info":[{"award-number":["RO1 HL085188"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:p> In critical illness, such as sepsis or the acute respiratory distress syndrome, acute kidney injury (AKI) is common and associated with increased morbidity and mortality. Mechanical ventilation in critical illnesses is also a risk factor for AKI, but it is potentially modifiable. Injurious ventilation strategies may lead to the systemic release of inflammatory mediators from the lung due to ventilator induced lung injury (VILI). The systemic consequences of VILI are difficult to differentiate clinically from other systemic inflammatory syndromes, such as sepsis. The purpose of this study was to identify unique changes in the expression of inflammatory mediators in kidney tissue in response to VILI compared with systemic sepsis to gain insight into direct effects of VILI on the kidney. Four groups of mice were compared\u2014mice with sepsis from cecal ligation and puncture (CLP), mice subjected to injurious mechanical ventilation with high tidal volumes (VILI), mice exposed to CLP followed by VILI (CLP+VILI), and sham controls. Protein expression of common inflammatory mediators in kidneys was analyzed using a proteome array and confirmed by Western blot analysis or ELISA. VEGF and VCAM-1 were found to be significantly elevated in kidneys from VILI mice compared with sham and CLP. Angiopoietin-2 was significantly increased in CLP+VILI compared with CLP alone and was also correlated with higher levels of AKI biomarker, neutrophil gelatinase-associated lipocalin. These results suggest that VILI alters the renal expression of VEGF, VCAM-1, and angiopoietin-2, and these proteins warrant further investigation as potential biomarkers and therapeutic targets. <\/jats:p>","DOI":"10.1152\/ajprenal.00523.2016","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T08:53:55Z","timestamp":1478768035000},"page":"F654-F660","source":"Crossref","is-referenced-by-count":60,"title":["Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney"],"prefix":"10.1152","volume":"312","author":[{"given":"Mark","family":"Hepokoski","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, California;"},{"name":"Veterans Affairs San Diego Healthcare System, San Diego, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Englert","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Baron","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-2660","authenticated-orcid":false,"given":"Laura E.","family":"Crotty-Alexander","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, California;"},{"name":"Veterans Affairs San Diego Healthcare System, San Diego, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Fuster","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, California;"},{"name":"Veterans Affairs San Diego Healthcare System, San Diego, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R.","family":"Beitler","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhleen","family":"Singh","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System, San Diego, California;"},{"name":"Division of Nephrology and Hypertension, University of California San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199303000-00027"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182451c87"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1216OC"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32730"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08300813"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.07.008"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101889"},{"key":"B10","first-page":"1029","volume":"146","author":"Dvorak HF","year":"1995","journal-title":"Am J Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3685"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000052"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/cc8168"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842182"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2104"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03090707"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/cc10282"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/cc7130"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.06.020"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01630407"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050834"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0108-x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.040204"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00365.2005"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2290"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.50.3.643"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197501000-00009"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520260039030"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9709092"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.525"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000524"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000224227.70642.4F"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/cc12743"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.01.010"},{"key":"B38","first-page":"647","volume":"77","author":"Villar J","year":"2011","journal-title":"Minerva Anestesiol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00263.2006"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/cc11145"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00336.2015"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00523.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T02:09:09Z","timestamp":1567994949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00523.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,1]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4,1]]}},"alternative-id":["10.1152\/ajprenal.00523.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00523.2016","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,1]]}}}