{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:51:15Z","timestamp":1793389875000,"version":"4.5.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2015,1,15]]},"abstract":"<jats:p>\n                    Plasma uric acid (PUA) is associated with metabolic, cardiovascular, and renal abnormalities in patients with type 2 diabetes but is less well understood in type 1 diabetes (T1D). Our aim was to compare PUA levels and fractional uric acid excretion (FE\n                    <jats:sub>UA<\/jats:sub>\n                    ) in patients with T1D vs. healthy controls (HC) during euglycemia and hyperglycemia. PUA, FE\n                    <jats:sub>UA<\/jats:sub>\n                    , blood pressure (BP), glomerular filtration rate (GFR-inulin), and effective renal plasma flow (ERPF-paraaminohippurate) were evaluated in patients with T1D ( n = 66) during clamped euglycemia (glucose 4\u20136 mmol\/l) and hyperglycemia (9\u201311 mmol\/l), and in HC ( n = 41) during euglycemia. To separate the effects of hyperglycemia vs. increased glycosuria, parameters were evaluated during clamped euglycemia in a subset of T1D patients before and after sodium glucose cotransporter 2 (SGLT2) inhibition for 8 wk. PUA was lower in T1D vs. HC (228 \u00b1 62 vs. 305 \u00b1 75 \u03bcmol\/l, P &lt; 0.0001). In T1D, hyperglycemia further decreased PUA (228 \u00b1 62 to 199 \u00b1 65 \u03bcmol\/l, P &lt; 0.0001), which was accompanied by an increase in FE\n                    <jats:sub>UA<\/jats:sub>\n                    (7.3 \u00b1 3.8 to 11.6 \u00b1 6.7, P &lt; 0.0001). In T1D, PUA levels correlated positively with SBP ( P = 0.029) and negatively with ERPF ( P = 0.031) and GFR ( P = 0.028). After induction of glycosuria with SGLT2 inhibition while maintaining clamped euglycemia, PUA decreased ( P &lt; 0.0001) and FE\n                    <jats:sub>UA<\/jats:sub>\n                    increased ( P &lt; 0.0001). PUA is lower in T1D vs. HC and positively correlates with SBP and negatively with GFR and ERPF in T1D. Glycosuria rather than hyperglycemia increases uricosuria in T1D. Future studies examining the effect of uric acid-lowering therapies should account for the impact of ambient glycemia, which causes an important uricosuric effect.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00555.2014","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T01:55:13Z","timestamp":1415325313000},"page":"F77-F83","source":"Crossref","is-referenced-by-count":156,"title":["Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus"],"prefix":"10.1152","volume":"308","author":[{"given":"Yuliya","family":"Lytvyn","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada;"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"\u0160krti\u0107","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Z. I.","family":"Cherney","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800156200"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312226200"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800737200"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101719"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1230"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2014.05.006"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00027.2010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1230"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005081"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.1909"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken066"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2005.00621.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000223447.53155.d5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12081"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0227"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.267"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01580210"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979093"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.01.010"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90376-X"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006040415"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90324-5"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp740"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.234"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11451210"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1159\/000324847"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084996"},{"key":"B28","first-page":"13","volume":"258","author":"Lewis G","year":"2014","journal-title":"Practitioner"},{"key":"B29","author":"Lytvyn Y","journal-title":"Can J Diabetes"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0381-0"},{"key":"B31","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1681\/ASN.V1081778","volume":"10","author":"Miller JA","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"B32","first-page":"128","volume":"4","author":"Momeni A","year":"2010","journal-title":"Iran J Kidney Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.1.E1"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.130013"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04271007"},{"key":"B36","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1152\/ajplegacy.1970.219.4.1080","volume":"219","author":"Skeith MD","year":"1970","journal-title":"Am J Physiol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038285"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.919907"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e318204aab4"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12038"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068908"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00555.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T12:43:57Z","timestamp":1650545037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00555.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1,15]]}},"alternative-id":["10.1152\/ajprenal.00555.2014"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00555.2014","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}