{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:30:13Z","timestamp":1783629013761,"version":"3.55.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:p> There is little clinical data of how hypertension may influence individuals with nephron deficiency in the context of being born with a single kidney. We recently developed a new rat model (the heterogeneous stock-derived model of unilateral renal agenesis rat) that is born with a single kidney and exhibits progressive kidney injury and decline in kidney function with age. We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy. Time course evaluation of blood pressure, kidney injury, and renal hemodynamics was performed in the following six groups of animals from weeks 13 to 18: 1) DOCA-treated rats with a solitary kidney (DOCA+S group), 2) placebo-treated rats with a solitary kidney, 3) DOCA-treated control rats with two kidneys (DOCA+C group), 4) placebo-treated control rats with two kidneys, 5) DOCA-treated rats with two kidneys that underwent uninephrectomy (DOCA+UNX8 group), and 6) placebo-treated rats with two kidneys that underwent uninephrectomy. DOCA+S rats demonstrated a significant rise ( P &lt; 0.05) in blood pressure (192 \u00b1 4 mmHg), proteinuria (205 \u00b1 31 mg\/24 h), and a decline in glomerular filtration rate (600 \u00b1 42 \u03bcl\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g kidney weight<jats:sup>\u22121<\/jats:sup>) relative to the DOCA+UNX8 (173 \u00b1 3 mmHg, 76 \u00b1 26 mg\/24 h, and 963 \u00b1 36 \u03bcl\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g kidney weight<jats:sup>\u22121<\/jats:sup>) and DOCA+C (154 \u00b1 2 mmHg, 7 \u00b1 1 mg\/24 h, and 1,484 \u00b1 121 \u03bcl\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g kidney weight<jats:sup>\u22121<\/jats:sup>) groups. Placebo-treated groups showed no significant change among the three groups. An assessment of renal injury markers via real-time PCR\/Western blot analysis and histological analysis was concordant with the measured physiological parameters. In summary, congenital solitary kidney rats are highly susceptible to the induction of hypertension compared with uninephrectomized rats, suggesting that low nephron endowment is an important driver of elevated blood pressure, hastening nephron injury through the transmission of elevated systemic blood pressure and thereby accelerating decline in kidney function. <\/jats:p>","DOI":"10.1152\/ajprenal.00555.2015","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T03:36:34Z","timestamp":1456976194000},"page":"F1054-F1064","source":"Crossref","is-referenced-by-count":19,"title":["Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats"],"prefix":"10.1152","volume":"310","author":[{"given":"Xuexiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Sasser","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah C.","family":"Solberg Woods","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;"},{"name":"Department of Medicine (Nephrology), University of Mississippi Medical Center, Jackson, Mississippi; 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