{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:48:29Z","timestamp":1767980909337,"version":"3.49.0"},"reference-count":51,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2014,5,15]]},"abstract":"<jats:p>The T-cell immunoglobulin mucin 1, also known as kidney injury molecule-1, modulates CD4+ T-cell responses and is also expressed by damaged proximal tubules within the kidney. Both Th subset imbalance (Th1\/Th2\/Th17) and regulatory T-cell and B-cell alterations contribute to the pathogenesis of autoimmune disease. This study investigated the effects of an inhibitory anti-T-cell immunoglobulin mucin 1 antibody (RMT1\u201310) in lupus-prone MRL- Fas<jats:sup>lpr<\/jats:sup>mice. MRL- Fas<jats:sup>lpr<\/jats:sup>mice were treated with RMT1\u201310 or a control antibody intraperitoneally twice weekly from 3 mo of age for 16 wk. RMT1\u201310 treatment significantly improved survival, limited the development of lymphadenopathy and skin lesions, preserved renal function and decreased proteinuria, reduced serum anti-DNA antibody levels, and attenuated renal leukocyte accumulation. Th1 and Th17 cellular responses systemically and intrarenally were reduced, but regulatory T and B cells were increased. RMT1\u201310 treatment also reduced glomerular immunoglobulin and C3 deposition and suppressed cellular proliferation and apoptosis. Urinary excretion and renal expression of kidney injury molecule-1 was reduced, reflecting diminished interstitial injury. As RMT1\u201310 attenuated established lupus nephritis, manipulating immune system T-cell immunoglobulin mucin 1 may represent a therapeutic strategy in autoimmune diseases affecting the kidney.<\/jats:p>","DOI":"10.1152\/ajprenal.00570.2013","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T04:09:24Z","timestamp":1394683764000},"page":"F1210-F1221","source":"Crossref","is-referenced-by-count":9,"title":["Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-<i>Fas<\/i><sup><i>lpr<\/i><\/sup>mice"],"prefix":"10.1152","volume":"306","author":[{"given":"Yuji","family":"Nozaki","sequence":"first","affiliation":[{"name":"Department of Hematology and Rheumatology, Kinki University School of Medicine, Osaka, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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