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Administration of doxycycline shortly after birth, but not at any other time point later in life, resulted in podocyte injury and development of classical FSGS lesions in these mice. Sclerotic lesions were formed as soon as 3 wk of age, and FSGS progressed with low variability until 13 wk of age. In addition, our experiments identified Cre toxicity as a potentially relevant limitation for studies in podocytes of transgenic animals. In summary, our study establishes a novel genetic model for FSGS in mice, which exhibits low variability and manifests already at a young age. <\/jats:p>","DOI":"10.1152\/ajprenal.00573.2018","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T07:27:56Z","timestamp":1570433276000},"page":"F1375-F1382","source":"Crossref","is-referenced-by-count":6,"title":["Cre recombinase toxicity in podocytes: a novel genetic model for FSGS in adolescent mice"],"prefix":"10.1152","volume":"317","author":[{"given":"Madeleine","family":"Frahsek","sequence":"first","affiliation":[{"name":"Nephrology and Clinical Immunology, University Hospital of RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schulte","sequence":"additional","affiliation":[{"name":"Nephrology and Clinical Immunology, University Hospital of RWTH Aachen University, Aachen, Germany"},{"name":"Department of Nephrology and 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