{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:10Z","timestamp":1787017750977,"version":"build-2736575974"},"reference-count":49,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K08992"],"award-info":[{"award-number":["16K08992"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K08566"],"award-info":[{"award-number":["21K08566"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03678"],"award-info":[{"award-number":["19H03678"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016243","name":"Teikyo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p>\n                    Electrogenic Na\n                    <jats:sup>+<\/jats:sup>\n                    \/[Formula: see text] cotransporter 1-A (NBCe1-A) in the proximal tubule regulates the acid\/base balance and fluid volume homeostasis. From the National Center for Biotechnology Information dbSNP database, we identified the I551F variant of NBCe1-A, which showed reduced glycosylation, cell surface expression, and transport activity. We also found that the I551F variant can exert a dominant negative effect on wild-type NBCe1-A, suggesting its physiological significance.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00584.2020","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T05:26:52Z","timestamp":1635744412000},"page":"F771-F784","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel I551F variant of the Na\n                    <sup>+<\/sup>\n                    \/HCO\n                    <sub>3<\/sub>\n                    <sup>\u2212<\/sup>\n                    cotransporter NBCe1-A shows reduced cell surface expression, resulting in diminished transport activity"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-403X","authenticated-orcid":true,"given":"Osamu","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan"},{"name":"Department of General Medicine, Keio University School of Medicine, Tokyo, Japan"},{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumika","family":"Ochiai-Homma","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Keio University School of Medicine, Tokyo, Japan"},{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Hirahashi","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Keio University School of Medicine, Tokyo, Japan"},{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kozuma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Fujigaki","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Seki","sequence":"additional","affiliation":[{"name":"Yaizu City Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matsuhiko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Keio University School of Medicine, Tokyo, Japan"},{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Tokyo, Japan"},{"name":"Kawakita General Hospital, Center for Clinical Education, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6868-0626","authenticated-orcid":true,"given":"Shigeru","family":"Shibata","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(00)00204-3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006060620"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.61.1.699"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.281.5.F920"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.277.2.G487"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-18-06839.2000"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11869"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.278.6.C1200"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/15440"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000025281.70901.30"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406591200"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004080667"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0319-y"},{"key":"B15","first-page":"324","volume":"12","author":"Demirci FY","year":"2006","journal-title":"Mol Vis"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V124713"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.523"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.320"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-004-1278-1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008705107"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/JP272252"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-018-0612-y"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1274-3"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607041200"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.2.F298"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00418.2002"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605545103"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007030289"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013060596"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0918-x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602250103"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1277-1"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.09.147"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00094.2006"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-009-9164-6"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aat5018"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/387409a0"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03271-3"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.093286"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00032.2005"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.127555"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00131.2002"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1113\/JP280143"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.001438"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00267.2006"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2012"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/ng.118"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-012-9421-y"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.619320"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00584.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T09:39:01Z","timestamp":1637573941000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00584.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12,1]]}},"alternative-id":["10.1152\/ajprenal.00584.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00584.2020","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]},"assertion":[{"value":"2020-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}