{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:27:41Z","timestamp":1790994461193,"version":"4.1.0"},"reference-count":46,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["HL116264"],"award-info":[{"award-number":["HL116264"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK96859"],"award-info":[{"award-number":["DK96859"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["15SFRN2391002"],"award-info":[{"award-number":["15SFRN2391002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p> Immune cells in the kidney are implicated in the development of hypertension and renal damage in the Dahl salt-sensitive (SS) rat. Interestingly, interleukin 6 (IL-6) mRNA is 54-fold higher in T-lymphocytes isolated from the kidney compared with circulating T-lymphocytes. The present experiments assessed the role of IL-6 in the development of SS hypertension by treating rats ( n = 13\u201314\/group) with an IL-6 neutralizing antibody or normal IgG during an 11-day period of high-salt (4.0% NaCl chow) intake. The mean arterial pressure (MAP) and urine albumin excretion rates (Ualb) were not different between the groups fed low salt (0.4% NaCl). Following 11 days of drug treatment and high salt, however, the rats receiving anti-IL-6 demonstrated a 47% reduction of IL-6 in the renal medulla compared with control SS. Moreover, the increase in MAP following 11 days of high-NaCl intake was significantly attenuated in SS administered anti-IL-6 compared with the control group (138 \u00b1 3 vs. 149 \u00b1 3 mmHg) as was the salt-induced increase in Ualb and glomerular and tubular damage. To investigate potential mechanisms of action, a flow cytometric analysis of immune cells in the kidney ( n = 8\u20139\/group) demonstrated that the total number of monocytes and macrophages was significantly lower in the treatment vs. the control group. The total number of T- and B-lymphocytes in the kidneys was not different between groups. These studies indicate that IL-6 production may participate in the development of SS hypertension and end-organ damage by mediating increased infiltration or proliferation of macrophages into the kidney. <\/jats:p>","DOI":"10.1152\/ajprenal.00594.2015","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T23:34:31Z","timestamp":1465428871000},"page":"F555-F561","source":"Crossref","is-referenced-by-count":88,"title":["Interleukin-6 inhibition attenuates hypertension and associated renal damage in Dahl salt-sensitive rats"],"prefix":"10.1152","volume":"311","author":[{"given":"Shireen","family":"Hashmat","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Rudemiller","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine M.","family":"Abais-Battad","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Van Why","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Mattson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00199.2002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02807-9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(89)90084-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001785"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.158071"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.113"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.146902"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00527.2007"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00298.2009"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00454.2010"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0507-z"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00466.2007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.6.803"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000095249.99803.85"},{"key":"B15","first-page":"130","volume":"125","author":"Harrison DG","year":"2014","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3109\/08830189809042997"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2014.09.004"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.923"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.023"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198710000-00005"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000116869.64771.5A"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00708.2005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00207.2009"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68770-9"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000248135.97380.76"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.145094"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000228320.23697.29"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00151.2003"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00304.2012"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000153318.74544.cc"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00258.2014"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303697"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.02.003"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00059.2006"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-2-199801150-00009"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02191"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04736"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76327"},{"key":"B40","first-page":"866","volume":"107","author":"Schmieder RE","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00602.2006"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90995.2008"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.26"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02283.x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.419788"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.173328"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00594.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:40:36Z","timestamp":1567975236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00594.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9,1]]}},"alternative-id":["10.1152\/ajprenal.00594.2015"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00594.2015","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]}}}