{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T13:18:29Z","timestamp":1776604709502,"version":"3.51.2"},"reference-count":26,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["R01 DK107450"],"award-info":[{"award-number":["R01 DK107450"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:p> To clarify the role of serotonin (5-HT) in the prevention of stress urinary incontinence (SUI) during sneezing, we investigated the effect of intraperitoneal application of p-chlorophenylalanine (PCPA; a serotonin synthesis inhibitor) and intravenous application of CP-809101 (a 5-HT<jats:sub>2C<\/jats:sub> agonist) or LP44 (a 5-HT<jats:sub>7<\/jats:sub> agonist) using female rats, in which the neurally evoked continence reflex during sneezing was examined. Amplitudes of urethral pressure response during sneezing (A-URS), urethral baseline pressure (UBP) at the middle urethra, and sneeze-induced leak point pressure (S-LPP) were measured in normal female adult rats with or without drug administration. PCPA decreased A-URS by 35.1 cmH<jats:sub>2<\/jats:sub>O and UBP by 13.3 cmH<jats:sub>2<\/jats:sub>O compared with normal rats. In PCPA-administrated rats, CP-809101 increased A-URS by 24.1 cmH<jats:sub>2<\/jats:sub>O and UBP by 15.1 cmH<jats:sub>2<\/jats:sub>O, and LP44 also increased A-URS by 20.6 cmH<jats:sub>2<\/jats:sub>O and UBP by 11.4 cmH<jats:sub>2<\/jats:sub>O compared with rats treated with PCPA alone. SUI was observed with S-LPP of 40.1 cmH<jats:sub>2<\/jats:sub>O in PCPA-administrated rats, in which CP-809101 and LP44 increased S-LPP by 28.0 and 15.2 cmH<jats:sub>2<\/jats:sub>O, respectively, compared with rats treated with PCPA alone. The effects of CP-809101 and LP44 were antagonized by SB-242084 (a selective 5-HT<jats:sub>2C<\/jats:sub> antagonist) and SB-269970 (a selective 5-HT<jats:sub>7<\/jats:sub> antagonist), respectively. These results indicate that activation of 5-HT receptors enhances the active urethral closure reflex during sneezing, at least in part via 5-HT<jats:sub>2C<\/jats:sub> and 5-HT<jats:sub>7<\/jats:sub> receptors. <\/jats:p>","DOI":"10.1152\/ajprenal.00614.2017","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T10:24:18Z","timestamp":1518603858000},"page":"F79-F85","source":"Crossref","is-referenced-by-count":13,"title":["Role of the serotonergic system in urethral continence reflexes during sneezing in rats"],"prefix":"10.1152","volume":"315","author":[{"given":"Takahisa","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"},{"name":"Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, 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