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In the aldosterone-sensitive distal nephron, the increased Na delivery stimulates K wasting due to an exaggerated exchange of epithelial Na channel-mediated Na reabsorption of secreted K. The effects of furosemide are different in mice fed a high-K, alkaline (HK) diet: the large-conductance Ca-activated K (BK) channel, in conjunction with the BK \u03b2<jats:sub>4<\/jats:sub>-subunit (BK-\u03b1\/\u03b2<jats:sub>4<\/jats:sub>), mediates K secretion from intercalated cells (IC) of the connecting tubule and collecting ducts. The urinary alkaline load is necessary for BK-\u03b1\/\u03b2<jats:sub>4<\/jats:sub>-mediated K secretion in HK diet-fed mice. However, furosemide acidifies the urine by increasing vacuolar ATPase expression and acid secretion from IC, thereby inhibiting BK-\u03b1\/\u03b2<jats:sub>4<\/jats:sub>-mediated K secretion and sparing K. In mice fed a low-Na, high-K (LNaHK) diet, furosemide causes a greater increase in plasma K concentration and reduction in K excretion than in HK diet-fed mice. Micropuncture of the early distal tubule of mice fed a LNaHK diet, but not a regular or a HK diet, reveals K secretion in the thick ascending limb of Henle\u2019s loop. The sites of action of K secretion in individuals consuming a high-K diet should be taken into account when diuretic agents known to waste K with low or moderate K intakes are prescribed.<\/jats:p>","DOI":"10.1152\/ajprenal.00614.2018","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T12:47:00Z","timestamp":1551876420000},"page":"F970-F973","source":"Crossref","is-referenced-by-count":2,"title":["Potassium-sparing effects of furosemide in mice on high-potassium diets"],"prefix":"10.1152","volume":"316","author":[{"given":"Bangchen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Sansom","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, 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