{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:49:53Z","timestamp":1777250993199,"version":"3.51.4"},"reference-count":36,"publisher":"American Physiological Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:p> Adriamycin (ADR) administration in susceptible rodents such as the BALB\/c mouse strain produces injury to the glomerulus mimicking human focal glomerular sclerosis. The goal of the present study was to use this model to investigate antiproteinuric action of nitro-oleic acid (OA-NO<jats:sub>2<\/jats:sub>), a nitric oxide-derived endogenous lipid product, which has exhibited multiple attractive signaling properties particularly in the kidney. BALB\/c mice were pretreated for 2 days with OA-NO<jats:sub>2<\/jats:sub> at 5 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> via an osmotic minipump, followed by a single injection of vehicle or adriamycin (10 mg\/kg) via the tail vein. Albuminuria and renal function were analyzed at 1 wk post-ADR treatment. ADR mice developed prominent albuminuria, hypoalbuminemia, hyperlipidemia, and severe ascites. In contrast, the symptoms of nephrotic syndrome were greatly improved by OA-NO<jats:sub>2<\/jats:sub> treatment. In parallel, plasma creatinine and plasma urea nitrogen were elevated in the ADR group, and the severity was less in the ADR+OA-NO<jats:sub>2<\/jats:sub> group. OA-NO<jats:sub>2<\/jats:sub> attenuates ADR-induced glomerulosclerosis, podocyte loss, and tubulointerstitial fibrosis. Indices of oxidative stress, including plasma and urinary thiobarbituric acid-reactive substances and renal expression of NAD(P)H oxidase p47<jats:sup>phox<\/jats:sup> and gp91<jats:sup>phox<\/jats:sup>, and inflammation, including renal expression of TNF-\u03b1, IL-1\u03b2, and MCP-1 in response to ADR, were all similarly suppressed. Together, these findings suggest that OA-NO<jats:sub>2<\/jats:sub> exerts renoprotective action against ADR nephropathy likely via its anti-inflammatory and antioxidant properties. <\/jats:p>","DOI":"10.1152\/ajprenal.00656.2012","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T05:48:23Z","timestamp":1363240103000},"page":"F1533-F1541","source":"Crossref","is-referenced-by-count":42,"title":["Nitro-oleic acid protects against adriamycin-induced nephropathy in mice"],"prefix":"10.1152","volume":"305","author":[{"given":"Shanshan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, Utah;"},{"name":"Veterans Affairs Medical Center, Salt Lake City, Utah;"},{"name":"Department of Nephrology, 2nd Affiliated Hospital, Shandong University, Jinan, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanjun","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, Utah;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Hypertension, Sun Yat-Sen University School of Medicine, Guangzhou, China,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, Utah;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ling","sequence":"additional","affiliation":[{"name":"Tissue Protection and Repair, Sanofi-Genzyme R&amp;D Center, Framingham, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nanjing Children's Hospital, Affiliated with Nanjing Medical University, Nanjing, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaomin","family":"Du","sequence":"additional","affiliation":[{"name":"Guangdong Provincial People's Hospital, Guangzhou, China; and"},{"name":"Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangju","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, 2nd Affiliated Hospital, Shandong University, Jinan, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, Utah;"},{"name":"Institute of Hypertension, Sun Yat-Sen University School of Medicine, Guangzhou, China,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000166844.42227.5c"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.4.R1064"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504212200"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.11.021"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32833aa4ac"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00592.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060592"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006090990"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603357200"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/snep.2003.50015"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007101109"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121236"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1639"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2008.10.003"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.178897"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.064873"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004121084"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90236.2008"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.28"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.108"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90421.2008"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011111130"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2009.00042.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp275"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000410"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008040434"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00261.2007"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000138"},{"key":"B29","volume":"2010","author":"Wang H","journal-title":"PPAR Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00439.2009"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00129.2012"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002222"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006060622"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1080\/10715760802657308"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.04.014"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.218404"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00656.2012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:50:08Z","timestamp":1567986608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00656.2012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,1]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,12,1]]}},"alternative-id":["10.1152\/ajprenal.00656.2012"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00656.2012","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,1]]}}}