{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:20:42Z","timestamp":1791080442189,"version":"4.1.0"},"reference-count":35,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p> We previously showed that the male streptozotocin (STZ)-induced diabetic rat exhibits decreased circulating testosterone and increased estradiol levels. While supplementation with dihydrotestosterone is partially renoprotective, the aim of the present study was to examine whether inhibition of estradiol synthesis, by blocking the aromatization of testosterone to estradiol using an aromatase inhibitor, can also prevent diabetes-associated renal injury. The study was performed on male Sprague-Dawley nondiabetic, STZ-induced diabetic, and STZ-induced diabetic rats treated with 0.15 mg\/kg of anastrozole, an aromatase inhibitor (Da) for 12 wk. Treatment with anastrozole reduced diabetes-associated increases in plasma estradiol by 39% and increased plasma testosterone levels by 187%. Anastrozole treatment also attenuated urine albumin excretion by 42%, glomerulosclerosis by 30%, tubulointerstitial fibrosis by 32%, along with a decrease in the density of renal cortical CD68-positive cells by 50%, and protein expression of transforming growth factor-\u03b2 by 20%, collagen type IV by 29%, tumor necrosis factor-\u03b1 by 28%, and interleukin-6 by 25%. Anastrozole also increased podocin protein expression by 18%. We conclude that blocking estradiol synthesis in male STZ-induced diabetic rats is renoprotective. <\/jats:p>","DOI":"10.1152\/ajprenal.00718.2010","type":"journal-article","created":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T23:32:54Z","timestamp":1307575974000},"page":"F634-F640","source":"Crossref","is-referenced-by-count":29,"title":["Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induced diabetic rats"],"prefix":"10.1152","volume":"301","author":[{"given":"Michaele B.","family":"Manigrasso","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics and the Women's Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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