{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:41:33Z","timestamp":1776703293478,"version":"3.51.2"},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[1982,7,1]]},"abstract":"<jats:p> Changes in plasma potassium ([K+]p) and insulin levels were monitored during K+ infusion in awake and anesthetized nephrectomized, splenectomized dogs. In dogs studied while anesthetized with pentobarbital, the increase in [K+]p was linear, reflecting a nearly constant rate of cellular uptake of the infused K+. In contrast, in dogs studied 18 h after nephrectomy while awake, [K+]p oscillated during infusion, reflecting an inconstant rate of cellular K+ uptake. Although these oscillations in [K+]p were associated with parallel oscillations in plasma insulin levels (suggesting the possibility of a physiological feedback control loop involving K+ and insulin), when the oscillations in insulin levels were blunted by somatostatin infusion or abolished by pancreatectomy plus insulin replacement, oscillations in [K+]p persisted and the average rate of cellular K+ uptake was not diminished. The observed oscillations of [K+]p during K+ infusion suggest the possibility of regulatory control of cellular K+ uptake within the pathophysiologic range of [K+]p. The putative control system is independent of and quantitatively more important than K+-induced insulin secretion and is obscured by pentobarbital anesthesia. <\/jats:p>","DOI":"10.1152\/ajprenal.1982.243.1.f44","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T08:49:57Z","timestamp":1513932597000},"page":"F44-F52","source":"Crossref","is-referenced-by-count":2,"title":["Oscillations of plasma K+ and insulin during K+ infusion in awake anephric dogs"],"prefix":"10.1152","volume":"243","author":[{"given":"R. H.","family":"Sterns","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.1982.243.1.F44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T14:15:45Z","timestamp":1567952145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.1982.243.1.F44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,7,1]]}},"alternative-id":["10.1152\/ajprenal.1982.243.1.F44"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.1982.243.1.f44","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7,1]]}}}