{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T19:29:12Z","timestamp":1715542152169},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[1983,8,1]]},"abstract":"<jats:p> Experiments were conducted in anesthetized dogs to evaluate the differences between the effects of intrarenal conversion of angiotensin I (ANG I) to angiotensin II (ANG II) and those of circulating ANG II on renal blood flow (RBF), glomerular filtration rate (GFR), peritubular capillary pressure (PCP), proximal tubular free-flow pressure (PTP), and stop-flow pressure (SFP). Equiconstrictor doses of ANG I and ANG II were infused into the renal arteries of dogs kept on normal and high sodium diets. In clearance experiments, RBF decreased by 23% (low dose) and 33% (high dose) during the infusion of either ANG I or ANG II; GFR was significantly reduced only during the ANG I infusion. In micropuncture experiments, in which the GFR responses were similar, there were significant reductions in PTP (23 +\/- 3%) and PCP (33 +\/- 3%) during the intrarenal ANG I infusion; SFP was not altered significantly. Afferent and efferent arteriolar resistances increased significantly during ANG I infusion as well as during infusion of ANG II. These results indicate that during intra-arterial infusion of ANG I, the conversion to ANG II within the kidney occurs early enough to decrease glomerular filtration rate through an apparent increase in preglomerular resistance. <\/jats:p>","DOI":"10.1152\/ajprenal.1983.245.2.f181","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T14:39:38Z","timestamp":1513953578000},"page":"F181-F187","source":"Crossref","is-referenced-by-count":9,"title":["Effects on renal hemodynamics of intra-arterial infusions of angiotensins I and II"],"prefix":"10.1152","volume":"245","author":[{"given":"L.","family":"Rosivall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. G.","family":"Navar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.1983.245.2.F181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:23:22Z","timestamp":1567967002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.1983.245.2.F181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,8,1]]}},"alternative-id":["10.1152\/ajprenal.1983.245.2.F181"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.1983.245.2.f181","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8,1]]}}}