{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T20:31:48Z","timestamp":1718656308856},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[1989,5,1]]},"abstract":"<jats:p> This review focuses on the basolateral membrane mechanisms of H-OH-HCO3 transport in the proximal tubule. The mechanism that has the greatest transport capacity and mediates most of transepithelial H-HCO3 transport is the electrogenic, Na-3HCO3 cotransporter. This transporter has been extensively characterized in the salamander, rat, and rabbit proximal tubule, and has now been found in a number of other epithelia that effect transepithelial NaHCO3 transport. Transporter rate is sensitive to intra- and extracellular [Na], intra- and extracellular [HCO3]\/pH, and cell voltage. Adaptations in transporter activity have been demonstrated in chronic metabolic acidosis and alkalosis, chronic respiratory acidosis and alkalosis, and chronic hyperfiltration. In addition to the Na-3HCO3 cotransporter, the basolateral membrane possesses both Na-dependent and -independent Cl-HCO3 exchangers, a H leak, and in the S3 proximal tubule an Na-H antiporter. The role of these H-OH-HCO3 transport mechanisms in transcellular HCO3 and Cl absorption and pHi defense is discussed. <\/jats:p>","DOI":"10.1152\/ajprenal.1989.256.5.f751","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T15:51:24Z","timestamp":1513957884000},"page":"F751-F765","source":"Crossref","is-referenced-by-count":4,"title":["Basolateral membrane H-OH-HCO3 transport in the proximal tubule"],"prefix":"10.1152","volume":"256","author":[{"given":"P. A.","family":"Preisig","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 77235-8856."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Alpern","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 77235-8856."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.1989.256.5.F751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:06:39Z","timestamp":1567955199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.1989.256.5.F751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,5,1]]}},"alternative-id":["10.1152\/ajprenal.1989.256.5.F751"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.1989.256.5.f751","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,5,1]]}}}