{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:57:00Z","timestamp":1718647020037},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[1993,3,1]]},"abstract":"<jats:p> We evaluated the effects of acid-base changes in pregnant and lactating dams on intercalated cell morphology and populations in newborn and 2-wk-old rats. Collecting ducts were studied with transmission electron microscopy with intercalated cells identified by the presence of 10-nm studs in the cytoplasmic face of apical membranes (A-type intercalated cells) or basolateral membranes (B-type intercalated cells). In newborn and 2-wk-old pups from dams with metabolic alkalosis, there was a significantly larger percentage of B-type intercalated cells and a smaller percentage of A-type intercalated cells. Acid loading with NH4Cl, however, did not produce an increase in the percentage of A-type intercalated cells, but reduced the percentage of B-type intercalated cells. We conclude that maternal metabolic alkalosis is associated with an increase in the percentage of B-type intercalated cells, suggesting that the initial differentiation of intercalated cells is responsive to maternal acid-base disturbances. <\/jats:p>","DOI":"10.1152\/ajprenal.1993.264.3.f415","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T10:41:53Z","timestamp":1514025713000},"page":"F415-F420","source":"Crossref","is-referenced-by-count":3,"title":["Induction of intercalated cell changes in rat pups from acid- and alkali-loaded mothers"],"prefix":"10.1152","volume":"264","author":[{"given":"R.","family":"Narbaitz","sequence":"first","affiliation":[{"name":"Department of Anatomy, University of Ottawa, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. K.","family":"Kapal","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Ottawa, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Z.","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Ottawa, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.1993.264.3.F415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:30:54Z","timestamp":1567974654000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.1993.264.3.F415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3,1]]}},"alternative-id":["10.1152\/ajprenal.1993.264.3.F415"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.1993.264.3.f415","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3,1]]}}}