{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T08:19:45Z","timestamp":1670314785479},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"<jats:p> We examined the effects of chronic intravenous neutral phosphate administration on systemic acid-base equilibrium and parathyroid function in six normal, NaCl-replete male human subjects under metabolic balance conditions. The subjects received 4.35 mmol of neutral sodium phosphate.kg body wt-1.day-1 intravenously and continuously for 7 days and the same amount of sodium as NaCl during control and recovery. Blood pH increased from 7.388 to 7.411 (P &lt; 0.001) and plasma bicarbonate from 23.5 to 26.0 mmol\/l (P &lt; 0.001). Urinary pH increased from 6.58 to 6.79 (P &lt; 0.001). Net acid excretion increased from 59 to 100 mmol\/24 h (P &lt; 0.001). Plasma ionized calcium concentration decreased and plasma phosphate concentration increased transiently. Serum intact parathyroid hormone increased from 24 to 62 pg\/ml (P &lt; 0.001). Chronic phosphate administration also resulted in a significant increase in renal phosphate clearance (35 to 229 ml\/min) and decrease in the fractional excretion of calcium (1.8 to 0.9%). Thus chronic intravenous phosphate administration generates and maintains renal metabolic alkalosis in salt-replete humans and induces hyperparathyroidism. The severity of metabolic alkalosis is mitigated by an apparent increase in effective endogenous acid production as evidenced by the significant increase in steady-state net acid excretion. <\/jats:p>","DOI":"10.1152\/ajprenal.1995.268.5.f802","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T01:21:07Z","timestamp":1513992067000},"page":"F802-F807","source":"Crossref","is-referenced-by-count":3,"title":["Neutral phosphate administration generates and maintains renal metabolic alkalosis and hyperparathyroidism"],"prefix":"10.1152","volume":"268","author":[{"given":"R.","family":"Krapf","sequence":"first","affiliation":[{"name":"Klinik B fur Innere Medizin, Kantonsspital, St. Gallen,Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Glatz","sequence":"additional","affiliation":[{"name":"Klinik B fur Innere Medizin, Kantonsspital, St. Gallen,Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. N.","family":"Hulter","sequence":"additional","affiliation":[{"name":"Klinik B fur Innere Medizin, Kantonsspital, St. Gallen,Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.1995.268.5.F802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:01:54Z","timestamp":1567958514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.1995.268.5.F802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5,1]]}},"alternative-id":["10.1152\/ajprenal.1995.268.5.F802"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.1995.268.5.f802","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,1]]}}}