{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:21:52Z","timestamp":1791328912592,"version":"4.3.1"},"reference-count":193,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>Pharmacological and physiological phenomena suggest that cells somewhere inside the central nervous system are responsive to aldosterone. Here, we present the fundamental physiological limitations for aldosterone action in the brain, including its limited blood-brain barrier penetration and its substantial competition from glucocorticoids. Recently, a small group of neurons with unusual sensitivity to circulating aldosterone were identified in the nucleus of the solitary tract. We review the discovery and characterization of these neurons, which express the enzyme 11\u03b2-hydroxysteroid dehydrogenase type 2, and consider alternative proposals regarding sites and mechanisms for mineralocorticoid action within the brain.<\/jats:p>","DOI":"10.1152\/ajprenal.90399.2008","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T21:10:05Z","timestamp":1236201005000},"page":"F559-F576","source":"Crossref","is-referenced-by-count":162,"title":["Aldosterone in the brain"],"prefix":"10.1152","volume":"297","author":[{"given":"Joel C.","family":"Geerling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur D.","family":"Loewy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04929.x"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Agarwal AK\n                      , Monder C, Eckstein B, White PC.\n                      Cloning and expression of rat cDNA encoding corticosteroid 11\u03b2-dehydrogenase.\n                      J Biol Chem\n                      264\n                      : 18939\u201318943, 1989.","DOI":"10.1016\/S0021-9258(19)47248-7"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Agarwal AK\n                      , Mune T, Monder C, White PC.\n                      NAD\n                      +\n                      -dependent isoform of 11\u03b2-hydroxysteroid dehydrogenase. Cloning and characterization of cDNA from sheep kidney.\n                      J Biol Chem\n                      269\n                      : 25959\u201325962, 1994.","DOI":"10.1016\/S0021-9258(18)47142-6"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1159\/000126593"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130312"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Ahokoski O\n                      , Virtanen A, Kairisto V, Scheinin H, Huupponen R, Irjala K.\n                      Biological day-to-day variation and reference change limits of serum cortisol and aldosterone in healthy young men on unrestricted diets.\n                      Clin Chem\n                      45\n                      : 1097\u20131099, 1999.","DOI":"10.1093\/clinchem\/45.7.1097"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1983.tb00038.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-111-5-1683"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90136-5"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Atarashi K\n                      , Matsuoka H, Takagi M, Yamada K, Hirata Y, Hayakawa H, Sugimoto T.\n                      Effects of intracerebroventricular infusion of aldosterone on blood pressure and sodium and potassium concentrations in cerebral spinal fluid in rats.\n                      Clin Exp Hypertens A\n                      10\n                      Suppl\n                      1: 317\u2013322, 1988.","DOI":"10.3109\/10641968809075985"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103747"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040401"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1210\/endo-113-6-2043"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00963982"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01963313"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1059"},{"key":"R17","unstructured":"Brody MJ\n                      .\n                      Central nervous system and mechanisms of hypertension.\n                      Clin Physiol Biochem\n                      6\n                      : 230\u2013239, 1988."},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.2.8593833"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198409000-00017"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(96)03775-6"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903480103"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903260207"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00371.1998"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.11.1337"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.5.H1516"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00437.2007"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91291-0"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.10.7664690"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06017"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00763-9"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(96)00048-1"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09273.x"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009159"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00971.x"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1038\/35000212"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.97.4.667"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-07-02570.1998"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108536"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(84)90038-5"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.06.002"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.03.009"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90742-8"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.03.046"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.2973"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.521625"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.97.5.746"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.5.H2241"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(66)90043-6"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.12.8940344"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200209000-00011"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.054"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1126\/science.2845584"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.05.072"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3115-05.2006"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20808"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21019"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20993"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.07.091"},{"key":"R59","unstructured":"Geerling JC\n                      , Loewy AD.\n                      11\u03b2-Hydroxysteroid dehydrogenase 2 vs. transgene: discrepant loci of expression in the adult brain.\n                      Am J Physiol Renal Physiol\n                      293\n                      : F440\u2013F443, 2007."},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00391.2006"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21452"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.039891"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.07.008"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4026.1133"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0860"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1080\/07435809609043732"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.8.5326"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-2-819"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1997.0157"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00355.2004"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.1.E96"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.3.E482"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.263.6.E1125"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00441.2004"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.4.E649"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.5.1133"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2150"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1990.259.6.R1131"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1988.255.6.H1349"},{"key":"R81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.12.013"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.02.004"},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1993.1006"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.09.037"},{"key":"R85","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2005.12.002"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000231398.64362.94"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.5.H1881"},{"key":"R88","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90352.2008"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb02744.x"},{"key":"R90","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(00)00112-7"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1037\/h0033798"},{"key":"R92","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1990.259.5.R1025"},{"key":"R93","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90296-9"},{"key":"R94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09272.x"},{"key":"R95","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.6.750"},{"key":"R96","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1260501"},{"key":"R97","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21409"},{"key":"R98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507572102"},{"key":"R99","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1984.247.3.H422"},{"key":"R100","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00671.2002"},{"key":"R101","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1226"},{"key":"R102","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.2.H646"},{"key":"R103","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4445"},{"key":"R104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14924"},{"key":"R105","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90942-7"},{"key":"R106","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.19.6056"},{"key":"R107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2006.04326.x"},{"key":"R108","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-5-2390"},{"key":"R109","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-4-1741"},{"key":"R110","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(90)90024-6"},{"key":"R111","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1102"},{"key":"R112","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200206000-00034"},{"key":"R113","doi-asserted-by":"publisher","DOI":"10.1038\/nature04767"},{"key":"R114","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90554-2"},{"key":"R115","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0240321"},{"key":"R116","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0427"},{"key":"R117","unstructured":"Malinow KC\n                      , Lion JR.\n                      Hyperaldosteronism (Conn's disease) presenting as depression.\n                      J Clin Psychiatry\n                      40\n                      : 358\u2013359, 1979."},{"key":"R118","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0151"},{"key":"R119","doi-asserted-by":"crossref","unstructured":"McCance RA\n                      .\n                      Experimental human salt deficiency.\n                      Lancet\n                      1\n                      : 823\u2013830, 1936.","DOI":"10.1016\/S0140-6736(01)36734-X"},{"key":"R120","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.5.1575"},{"key":"R121","doi-asserted-by":"publisher","DOI":"10.1210\/endo.130.1.1727721"},{"key":"R122","doi-asserted-by":"publisher","DOI":"10.1210\/endo.130.1.1727713"},{"key":"R123","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-3-1450"},{"key":"R124","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.3.571"},{"key":"R125","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-3-15"},{"key":"R126","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(98)00009-0"},{"key":"R127","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00188.2006"},{"key":"R128","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.265.6.F896"},{"key":"R129","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-1-17"},{"key":"R130","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.97"},{"key":"R131","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730206"},{"key":"R132","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90123-X"},{"key":"R133","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00325.2007"},{"key":"R134","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0480169"},{"key":"R135","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-2-1-103"},{"key":"R136","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1979.tb05192.x"},{"key":"R137","doi-asserted-by":"crossref","unstructured":"Pardridge WM\n                      , Mietus LJ.\n                      Transport of protein-bound steroid hormones into liver in vivo.\n                      Am J Physiol Endocrinol Metab Gastrointest Physiol\n                      237\n                      : E367\u2013E372, 1979.","DOI":"10.1152\/ajpendo.1979.237.4.E367"},{"key":"R138","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109433"},{"key":"R139","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000194251.61554.6b"},{"key":"R140","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1990.259.5.F839"},{"key":"R141","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901510204"},{"key":"R142","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29148"},{"key":"R143","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200209000-00029"},{"key":"R144","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-01-00065.1996"},{"key":"R145","doi-asserted-by":"publisher","DOI":"10.1210\/endo-117-6-2505"},{"key":"R146","doi-asserted-by":"publisher","DOI":"10.1210\/endo-33-2-106"},{"key":"R147","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(94)90114-7"},{"key":"R148","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00161-2"},{"key":"R149","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(95)03539-J"},{"key":"R150","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.10.7664691"},{"key":"R151","doi-asserted-by":"publisher","DOI":"10.1126\/science.3131879"},{"key":"R152","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.251.4.R762"},{"key":"R153","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.11.044"},{"key":"R154","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1996.0143"},{"key":"R155","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.05.059"},{"key":"R156","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21245"},{"key":"R157","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)90406-7"},{"key":"R158","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21870"},{"key":"R159","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.058"},{"key":"R160","doi-asserted-by":"publisher","DOI":"10.1159\/000093956"},{"key":"R161","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.11.011"},{"key":"R162","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113592"},{"key":"R163","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91014-2"},{"key":"R164","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.6.R1082"},{"key":"R165","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00140-N"},{"key":"R166","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.062265"},{"key":"R167","doi-asserted-by":"crossref","unstructured":"Ueda K\n                      , Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R.\n                      Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.\n                      J Biol Chem\n                      267\n                      : 24248\u201324252, 1992.","DOI":"10.1016\/S0021-9258(18)35757-0"},{"key":"R168","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2002.00836.x"},{"key":"R169","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-5-757"},{"key":"R170","doi-asserted-by":"publisher","DOI":"10.1159\/000126832"},{"key":"R171","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1994.267.6.E921"},{"key":"R172","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1994.267.6.E927"},{"key":"R173","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-1-118"},{"key":"R174","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(91)90111-U"},{"key":"R175","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(83)90009-0"},{"key":"R176","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.024"},{"key":"R177","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.5.571"},{"key":"R178","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01487-X"},{"key":"R179","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198710000-00003"},{"key":"R180","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490250034004"},{"key":"R181","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10663"},{"key":"R182","doi-asserted-by":"publisher","DOI":"10.3758\/BF03342870"},{"key":"R183","doi-asserted-by":"crossref","unstructured":"Wolf G\n                      .\n                      Effect of deoxycorticosterone on sodium appetite of intact and adrenalectomized rats.\n                      Am J Physiol\n                      208\n                      : 1281\u20131285, 1965.","DOI":"10.1152\/ajplegacy.1965.208.6.1281"},{"key":"R184","doi-asserted-by":"publisher","DOI":"10.1210\/endo-78-6-1120"},{"key":"R185","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0439"},{"key":"R186","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0109"},{"key":"R187","doi-asserted-by":"publisher","DOI":"10.1042\/cs0950687"},{"key":"R188","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91555-1"},{"key":"R189","doi-asserted-by":"crossref","unstructured":"Yoshida K\n                      , McCormack S, Espana RA, Crocker A, Scammell TE.\n                      Afferents to the orexin neurons of the rat brain.\n                      J Comp Neurol\n                      494\n                      : 845\u2013861, 2005.","DOI":"10.1002\/cne.20859"},{"key":"R190","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00041-2"},{"key":"R191","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.099796"},{"key":"R192","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00685.2001"},{"key":"R193","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000224296.96235.dd"},{"key":"R194","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.9.7649078"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.90399.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T13:40:31Z","timestamp":1633182031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.90399.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":193,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1152\/ajprenal.90399.2008"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.90399.2008","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}