{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:50:27Z","timestamp":1772164227915,"version":"3.50.1"},"reference-count":74,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    Previous studies demonstrated changes in urinary bladder neurotrophin content and upregulation of neurotrophin receptors, TrkA and the p75 neurotrophin receptor (p75\n                    <jats:sup>NTR<\/jats:sup>\n                    ), in micturition reflex pathways after cyclophosphamide (CYP)-induced cystitis. p75\n                    <jats:sup>NTR<\/jats:sup>\n                    can bind nerve growth factor (NGF) and modulate NGF-TrkA binding and signaling. We examined p75\n                    <jats:sup>NTR<\/jats:sup>\n                    expression and the role of p75\n                    <jats:sup>NTR<\/jats:sup>\n                    in the micturition reflex in control and CYP-treated rats. p75\n                    <jats:sup>NTR<\/jats:sup>\n                    Immunoreactivity was present throughout the urinary bladder. CYP-induced cystitis (4 h, 48 h, chronic) increased ( P \u2264 0.05) p75\n                    <jats:sup>NTR<\/jats:sup>\n                    expression in whole urinary bladder as shown by Western blotting. The role of p75\n                    <jats:sup>NTR<\/jats:sup>\n                    in bladder function in control and CYP-treated rats was determined using conscious cystometry and immunoneutralization or PD90780, a compound known to specifically block NGF binding to p75\n                    <jats:sup>NTR<\/jats:sup>\n                    . An anti-p75\n                    <jats:sup>NTR<\/jats:sup>\n                    monoclonal antibody or PD90780 was infused intravesically and cystometric parameters were evaluated. Both methods of p75\n                    <jats:sup>NTR<\/jats:sup>\n                    blockade significantly ( P \u2264 0.05) decreased the intercontraction interval and void volume in control and CYP-treated rats. Intravesical infusion of PD90780 also significantly ( P \u2264 0.001) increased intravesical pressure and increased the number of nonvoiding contractions during the filling phase. Control intravesical infusions of isotype-matched IgG and vehicle were without effect. Intravesical instillation of PD90780 significantly ( P \u2264 0.01) reduced the volume threshold to elicit a micturition contraction in control rats (no inflammation) and CYP-treated in a closed urinary bladder system. These studies demonstrate 1) ubiquitous p75\n                    <jats:sup>NTR<\/jats:sup>\n                    expression in urinary bladder and increased expression with CYP-induced cystitis and 2) p75\n                    <jats:sup>NTR<\/jats:sup>\n                    blockade at the level of the urinary bladder produces bladder hyperreflexia in control and CYP-treated rats. The overall activity of the urinary bladder reflects the balance of NGF-p75\n                    <jats:sup>NTR<\/jats:sup>\n                    and NGF-TrkA signaling.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.90501.2008","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T20:45:36Z","timestamp":1223498736000},"page":"F1778-F1789","source":"Crossref","is-referenced-by-count":45,"title":["Role of p75\n                    <sup>NTR<\/sup>\n                    in female rat urinary bladder with cyclophosphamide-induced cystitis"],"prefix":"10.1152","volume":"295","author":[{"given":"Mary Beth","family":"Klinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret 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