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The role of IL-1 signaling has been established in the context of T cell differentiation and function, particularly in its regulation of T follicular helper (TFH) cells. Recent work has demonstrated that with TFH function primarily acting within the germinal center (GC), a local source of IL-1\u03b2 must be present, identifying GC B cells as a critical source of IL-1\u03b2. Here we discuss the roles of cells within the GC milieu, the cytokines they produce, and their impact on the GC. In addition, we also discuss the findings from studies examining the molecular mechanisms underlying IL-1\u03b2 production in B cells and its impact on B cell function. This review is especially relevant as it draws together findings from various disease pathologies to consolidate our current understanding of B cell subsets producing IL-1\u03b2 and IL-1\u03b2 signaling within the GC, in both T cells and B cells.<\/jats:p>","DOI":"10.1152\/function.105.2025","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:58:17Z","timestamp":1776106697000},"source":"Crossref","is-referenced-by-count":0,"title":["An \u201cold\u201d cytokine\u2019s new trick: IL-1\u03b2 in B cells and the germinal center"],"prefix":"10.1152","volume":"7","author":[{"given":"Juliana","family":"Restrepo Munera","sequence":"first","affiliation":[{"name":"Department of Cell and Biological Systems","place":["Hershey, United States"]},{"name":"Penn State College of Medicine","place":["Hershey, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise M.","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Department of Cell and Biological Systems","place":["Hershey, United States"]},{"name":"Penn State College of Medicine","place":["Hershey, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-1931","authenticated-orcid":false,"given":"S. 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