{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T08:24:13Z","timestamp":1648974253125},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1959,3,1]]},"abstract":"<jats:p> Perphenazine, a drug with high activity against apomorphine-induced vomiting in dogs, and Systral, an antiemetic analogue of benadryl with little or no activity against apomorphine-induced vomiting in dogs, were tested for antimotion sickness activity in human beings aboard aircraft. Neither furnished any protection. Further, dogs were swing-tested after the administration of chlorpromazine and perphenazine. In spite of the significant difference in protection against apomorphine-induced vomiting afforded by the two drugs (perphenazine much greater than chlorpromazine), perphenazine failed to protect against swing-induced vomiting and chlorpromazine furnished only 25% protection. These data emphasize the unreliability of extending the results of apomorphine inhibition to the relationship of the chemoceptive trigger zone to motion sickness. <\/jats:p><jats:p> Submitted on September 12, 1958 <\/jats:p>","DOI":"10.1152\/jappl.1959.14.2.245","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T17:29:50Z","timestamp":1514136590000},"page":"245-246","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of perphenazine and Systral against motion sickness"],"prefix":"10.1152","volume":"14","author":[{"given":"Lawrence J.","family":"Milch","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Biochemistry, School of Aviation Medicine, USAF, Randolph Air Force Base, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold D.","family":"Frankl","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Biochemistry, School of Aviation Medicine, USAF, Randolph Air Force Base, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Renzi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Biochemistry, School of Aviation Medicine, USAF, Randolph Air Force Base, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1959.14.2.245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:44:23Z","timestamp":1567993463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1959.14.2.245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1959,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1959,3,1]]}},"alternative-id":["10.1152\/jappl.1959.14.2.245"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1959.14.2.245","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1959,3,1]]}}}