{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:02Z","timestamp":1785250922582,"version":"3.55.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1963,5,1]]},"abstract":"<jats:p> The present study was designed to separate quantitatively the relative contributions of (H+) and Pco<jats:sub>2<\/jats:sub> as chemoreceptor stimuli. The integrated electrical activity from the entire Hering's nerve of the cat was measured and correlated with values of (H<jats:sup>+<\/jats:sup>), Pco<jats:sub>2<\/jats:sub>, and Po<jats:sub>2<\/jats:sub> of arterial blood. By utilizing a combination of respiratory and metabolic acidosis or alkalosis, the effect of (H<jats:sup>+<\/jats:sup>) on carotid body nerve activity could be separated from that of Pco<jats:sub>2<\/jats:sub>. Most studies were performed at high Po<jats:sub>2<\/jats:sub>, a few against a changing hypoxic background. The results indicate: 1) the pre-eminence of (H<jats:sup>+<\/jats:sup>) as a chemoreceptor stimulus, CO<jats:sub>2<\/jats:sub> acting only by virtue of its effect in altering (H<jats:sup>+<\/jats:sup>); 2) the relationship between (H<jats:sup>+<\/jats:sup>) or Pco<jats:sub>2<\/jats:sub> and chemoreceptor activity is nonlinear; 3) the potentiation between hypoxia and hypercapnia at the chemoreceptor level is due primarily to interaction between low oxygen tension and increased (H<jats:sup>+<\/jats:sup>), independent of Pco<jats:sub>2<\/jats:sub>. The significance of these findings to the exchange of CO<jats:sub>2<\/jats:sub> and of (H<jats:sup>+<\/jats:sup>) and (HCO3<jats:sup>-<\/jats:sup>) ions between the intracellular and extracellular milieu of the carotid chemoreceptor cells is discussed. <\/jats:p><jats:p> Submitted on September 28, 1962 <\/jats:p>","DOI":"10.1152\/jappl.1963.18.3.580","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T22:47:54Z","timestamp":1514155674000},"page":"580-584","source":"Crossref","is-referenced-by-count":77,"title":["Specificity of H ion concentration as a carotid chemoreceptor stimulus"],"prefix":"10.1152","volume":"18","author":[{"given":"Thomas F.","family":"Hornbein","sequence":"first","affiliation":[{"name":"Laboratory of Thoracic Physiology, Division of Anesthesiology, and Department of Physiology, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Roos","sequence":"additional","affiliation":[{"name":"Laboratory of Thoracic Physiology, Division of Anesthesiology, and Department of Physiology, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1963.18.3.580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:03:49Z","timestamp":1567998229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1963.18.3.580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1963,5,1]]}},"alternative-id":["10.1152\/jappl.1963.18.3.580"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1963.18.3.580","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,5,1]]}}}