{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:35:44Z","timestamp":1771644944714,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1963,11,1]]},"abstract":"<jats:p> Measurements of oral temperature, pulse rate, blood pressure, expired minute volume (Ve), respiratory rate (f), O<jats:sub>2<\/jats:sub> consumption (Vo<jats:sub>2<\/jats:sub>), CO<jats:sub>2<\/jats:sub> excretion (Vco<jats:sub>2<\/jats:sub>), breath-holding pulmonary diffusing capacity (Dl<jats:sub>CO<\/jats:sub>), dynamic pulmonary compliance (C<jats:sub>dyn<\/jats:sub>), and total pulmonary resistance were made on six normal adults before and at regular intervals over an 8-hr period following the induction of fever with triple typhoid vaccine. Although Ve, f, Vo<jats:sub>2<\/jats:sub> increased during the chill, flush, and defervescence phases of fever, there was no significant change in C<jats:sub>dyn<\/jats:sub> and total pulmonary resistance. Of interest was the slight, though statistically significant decrease in Dl<jats:sub>CO<\/jats:sub> during the flush and defervescence phases. Results suggest a low temperature coefficient for the mechanical properties of the lung in the range studied. The absence of an increased Dl<jats:sub>CO<\/jats:sub> during the flush phase of fever when Ve and the cardiac output are known to increase suggests that ventilation and pulmonary blood flow are not important determinants of Dl<jats:sub>CO<\/jats:sub>. <\/jats:p><jats:p> lung mechanics; ventilation <\/jats:p><jats:p> Submitted on February 18, 1963 <\/jats:p>","DOI":"10.1152\/jappl.1963.18.6.1065","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T23:10:33Z","timestamp":1514157033000},"page":"1065-1070","source":"Crossref","is-referenced-by-count":9,"title":["Effects of fever on pulmonary diffusing capacity and pulmonary mechanics in man"],"prefix":"10.1152","volume":"18","author":[{"given":"Leon","family":"Cander","sequence":"first","affiliation":[{"name":"Pulmonary Laboratory, Pratt Clinic-New England Center Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest G.","family":"Hanowell","sequence":"additional","affiliation":[{"name":"Pulmonary Laboratory, Pratt Clinic-New England Center Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1963.18.6.1065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:12:16Z","timestamp":1567998736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1963.18.6.1065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1963,11,1]]}},"alternative-id":["10.1152\/jappl.1963.18.6.1065"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1963.18.6.1065","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,11,1]]}}}