{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:26:59Z","timestamp":1791048419634,"version":"4.1.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1965,5,1]]},"abstract":"<jats:p>\n                    In chronic acid-base disturbances, CSF p\n                    <jats:sup>H<\/jats:sup>\n                    was generally within the normal limits (7.30\u20137.36 units, being the range including two standard deviations of 12 normal subjects). The mean values of CSF and arterial pH\n                    <jats:sup>H<\/jats:sup>\n                    , respectively, were: 1) metabolic alkalosis, 7.337 and 7.523; 2) metabolic acidosis, 7.315 and 7.350; 3) respiratory alkalosis, 7.336 and 7.485; and 4) respiratory acidosis (untreated), 7.314 and 7.382. Other investigators report similar values. The constancy of CSF p\n                    <jats:sup>H<\/jats:sup>\n                    cannot be explained by a poorly permeable blood-CSF barrier in chronic metabolic acidosis and alkalosis, nor can it be explained by respiratory compensation. It cannot be explained by renal compensation in respiratory alkalosis (high altitude for 8 days), although it may be explained by renal compensation in respiratory acidosis. The former three states suggest that active transport regulation of CSF p\n                    <jats:sup>H<\/jats:sup>\n                    is a function of the blood-CSF barrier. Since CSF p\n                    <jats:sup>H<\/jats:sup>\n                    is constant, so also must that portion of the respiratory drive originating in the superficial medullary respiratory chemoreceptors be constant. Ventilation changes in chronic acid-base disturbances thus may result from changes in the activity of peripheral chemoreceptors, in response to changes in arterial p\n                    <jats:sup>H<\/jats:sup>\n                    , arterial PO\n                    <jats:sub>2<\/jats:sub>\n                    , and possibly in neuromuscular receptors.\n                  <\/jats:p>\n                  <jats:p>regulation of respiration; medullary respiratory; chemoreceptors; peripheral chemoreceptors; metabolic acidosis and alkalosis; respiratory acidosis and alkalosis; active transport; blood-brain barrier; pregnancy<\/jats:p>\n                  <jats:p>Submitted on July 27, 1964<\/jats:p>","DOI":"10.1152\/jappl.1965.20.3.443","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T15:21:02Z","timestamp":1514128862000},"page":"443-452","source":"Crossref","is-referenced-by-count":131,"title":["Stability of cerebrospinal fluid pH in chronic acid-base disturbances in blood"],"prefix":"10.1152","volume":"20","author":[{"given":"R. A.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute and Departments of Anesthesia and Medicine, University of California Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. T.","family":"Carman","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute and Departments of Anesthesia and Medicine, University of California Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Severinghaus","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute and Departments of Anesthesia and Medicine, University of California Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute and Departments of Anesthesia and Medicine, University of California Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Singer","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute and Departments of Anesthesia and Medicine, University of California Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shnider","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute and Departments of Anesthesia and Medicine, University of California Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1965.20.3.443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:21:45Z","timestamp":1567981305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1965.20.3.443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1965,5,1]]}},"alternative-id":["10.1152\/jappl.1965.20.3.443"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1965.20.3.443","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,5,1]]}}}