{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:23:00Z","timestamp":1760955780509},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1975,10,1]]},"abstract":"<jats:p> Diastolic pressure-volume (P-V) curves were calculated on a beat-to-beat basis in the open-chest, pentobarbital-anesthetized dog, using the technique of direct transmitral flow measurement previously described. P-V curves were constructed and the slope (dP\/dV) was plotted vs. pressure and time. dP\/dV was used as an index of stiffness in each heart and its instantaneous changes with time were followed throughout the diastolic period. The end-diastolic P-V relation based on points from successive cycles during volume loading was found to be exponential. In contrast, the instantaneous P-V relation during any one diastolic period was not exponential. That is, the dynamic dP\/dV vs. pressure plot was nonlinear. In the normal heart, stiffness was characterized in early diastole by a negative dP\/dV as the ventricle continued to relax, and then frequently decreased prior to a second stiffness rise with atrial augmentation. These findings can be explained by a model containing an element whose deformation is rate dependent, i.e., a parallel viscous element. Stiffness profiles in mitral stenosis where dynamic effects are minimized substantiate this conclusion. <\/jats:p>","DOI":"10.1152\/jappl.1975.39.4.665","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T21:22:53Z","timestamp":1514150573000},"page":"665-671","source":"Crossref","is-referenced-by-count":39,"title":["Dynamic stiffness profiles in the left ventricle"],"prefix":"10.1152","volume":"39","author":[{"given":"A.","family":"Kennish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Yellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Frater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1975.39.4.665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:57:17Z","timestamp":1567987037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1975.39.4.665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1975,10,1]]}},"alternative-id":["10.1152\/jappl.1975.39.4.665"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1975.39.4.665","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,10,1]]}}}