{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:45:16Z","timestamp":1792665916645,"version":"4.5.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1977,6,1]]},"abstract":"<jats:p> A total of 252 untrained, unacclimatized, and unanesthetized laboratory rats weighing between 485 and 545 g were fasted and either run to exhaustion at 5, 20, 23, or 26 degrees C or were restrained and heated at an ambient temperature of 41.5 degrees C. The incidence of mortality associated with a wide range of work-induced hyperthermias was compared to the lethality of equivalent heat loads in the absence of physical effort. The severity of hyperthermia was calculated in degree-minutes above a base-line core temperature of 40.4 degrees C. The LD25\u2032s of run-exhausted versus restrained-heated rats were 16.8 and 30.1 deg-min, respectively. Survivors had a faster cooling rate than fatalities, but run-exhausted survivors had a slower cooling rate than restrained-heating survivors. Results indicate that 1) both the incidence of mortality and the survival time can be predicted from the severity of core heating, 2) work-related factors contribute to an increased rate of heatstroke death at low thermal loads, and 3) retrospectively, both heat-sensitive and heat-resistant groups were identified. <\/jats:p>","DOI":"10.1152\/jappl.1977.42.6.809","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T23:24:35Z","timestamp":1514157875000},"page":"809-816","source":"Crossref","is-referenced-by-count":95,"title":["Rat model of acute heatstroke mortality"],"prefix":"10.1152","volume":"42","author":[{"given":"R. W.","family":"Hubbard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. D.","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. T.","family":"Matthew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. C.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"Criss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Sheldon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Ratteree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1977.42.6.809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:17:07Z","timestamp":1567999027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1977.42.6.809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1977,6,1]]}},"alternative-id":["10.1152\/jappl.1977.42.6.809"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1977.42.6.809","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,6,1]]}}}