{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:27:12Z","timestamp":1790530032695,"version":"4.1.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1978,7,1]]},"abstract":"<jats:p> We studied the effects on breathing rhythm of suppressing the major respiratory stimuli (wakefulness, vagal, peripheral and central chemoreceptors) in healthy, unanesthetized dogs. Respiratory frequency (f) was obtained with a pneumotachograph; the state of wakefulness (W) or sleep was determined by EEG and behavioral criteria. During quiet W, f averaged 17 breaths\/min and minute volume of ventilation (VI), 8.4 l\/min. In slow-wave sleep (SWS), f slowed to 14 breaths\/min, and VI decreased to 6.8 l\/min. Afferent vagal blockade during SWS slowed f to 4 breaths\/min, due primarily to prolongation of expiratory duration (Te) to 13.3 s, and decreased VI to 4.8 l\/min. One breath of 100% O2 prolonged Te further to 27.4 s. Central chemoreceptor sensitivity was then reduced by inducting a metabolic alkalosis that combined with SWS, vagal blockade, and hyperoxia prolonged Te to as long as 57 s and reduced f to as low as 1 breath\/min. The results demonstrate that afferent respiratory stimuli are essential for sustaining adequate ventilation. <\/jats:p>","DOI":"10.1152\/jappl.1978.45.1.11","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T00:44:15Z","timestamp":1514162655000},"page":"11-17","source":"Crossref","is-referenced-by-count":74,"title":["Primary role of respiratory afferents in sustaining breathing rhythm"],"prefix":"10.1152","volume":"45","author":[{"given":"C. E.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. F.","family":"Kozar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Phillipson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1978.45.1.11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:37:24Z","timestamp":1568000244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1978.45.1.11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,7,1]]}},"alternative-id":["10.1152\/jappl.1978.45.1.11"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1978.45.1.11","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,7,1]]}}}