{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:20:14Z","timestamp":1769228414732,"version":"3.49.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1978,12,1]]},"abstract":"<jats:p> Steplike end-tidal hypoxic drives (Petcoco2, = 53 Torr) lasting for 5 min were generated in a group of normal subjects and a group of carotid body-resected subjects when end-tidal CO2, was maintained constant under eucapnic (Petcoco2 = 39 Torr) and hypercapnic (Petcoco2 = 49 Torr) conditions. The hypoxic ventilatory response of the normal subjects was prompt and significant in eucapnia and was enhanced in the hypercapnic state, evidencing CO2-O2 interaction. In contrast, the carotid body-resected subjects did not respond to eucapnic hypoxia but did demonstrate a small but significant ventilatory response to hypoxia against the hypercapnic background. This suggests that the aortic bodies in man may contribute a small component of the hypoxic ventilatory drive under hypercapnic conditions, although the possibility of neuromalike ending regeneration cannot be excluded. <\/jats:p>","DOI":"10.1152\/jappl.1978.45.6.971","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T00:20:02Z","timestamp":1514161202000},"page":"971-977","source":"Crossref","is-referenced-by-count":23,"title":["Effect of hypercapnia on hypoxic ventilatory drive in carotid body-resected man"],"prefix":"10.1152","volume":"45","author":[{"given":"George D.","family":"Swanson","sequence":"first","affiliation":[{"name":"1 Departments of Anesthesiology, Physiology and Medicine, University of California, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Whipp","sequence":"additional","affiliation":[{"name":"1 Departments of Anesthesiology, Physiology and Medicine, University of California, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"1 Departments of Anesthesiology, Physiology and Medicine, University of California, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel A.","family":"Aqleh","sequence":"additional","affiliation":[{"name":"1 Departments of Anesthesiology, Physiology and Medicine, University of California, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Winter","sequence":"additional","affiliation":[{"name":"1 Departments of Anesthesiology, Physiology and Medicine, University of California, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Weldon","family":"Bellville","sequence":"additional","affiliation":[{"name":"1 Departments of Anesthesiology, Physiology and Medicine, University of California, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1978.45.6.971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:31:29Z","timestamp":1567999889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1978.45.6.971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,12,1]]}},"alternative-id":["10.1152\/jappl.1978.45.6.971"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1978.45.6.971","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,12,1]]}}}