{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:55:28Z","timestamp":1774266928833,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1979,11,1]]},"abstract":"<jats:p> Nonhomogeneous lungs are predicted to exhibit time dependence of maximal expiratory flow (Vmax): faster regions would contribute more flow early in the expiration, whatever the initial volume, resulting in different Vmax at a given total lung volume, depending on how long flow limitation has been operating. To test this concept a new technique was developed that permits accurate superimposition of Vmax data over small volume intervals. When quick-release interrupted partial curves with similar volume history but different volume of initiation were compared over their late common-volume segments, the volume-history effects could be differentiated from time dependence of the Vmax. Such time dependence was found in 7 of 7 bronchitics, 3 of 5 smokers, and 0 of 14 nonsmokers tested. We conclude that the emptying during the forced expirations is not uniform even in mild disease states and the time dependence of Vmax is a sensitive test of lung inhomogeneity. <\/jats:p>","DOI":"10.1152\/jappl.1979.47.5.1043","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T05:49:04Z","timestamp":1514180944000},"page":"1043-1050","source":"Crossref","is-referenced-by-count":38,"title":["Time dependence of maximum flow as an index of nonuniform emptying"],"prefix":"10.1152","volume":"47","author":[{"given":"C. G.","family":"Melissinos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. K.","family":"Tien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1979.47.5.1043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:49:41Z","timestamp":1568008181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1979.47.5.1043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,11,1]]}},"alternative-id":["10.1152\/jappl.1979.47.5.1043"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1979.47.5.1043","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,11,1]]}}}