{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:26:55Z","timestamp":1771000015132,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1981,4,1]]},"abstract":"<jats:p> To test the relative importance of cholinergic effects on the Basenji-Greyhound (BG) model of asthma, we administered Ascaris antigen to Ascaris-sensitive BG dogs without other treatment, and following intravenous atropine. Pulmonary resistance (RL) increased from 1.4 +\/- 0.43 cmH2O . l-1 . s (mean + SE) to 26.0 +\/- 5.21 after Ascaris antigen exposure in seven untreated dogs. In the same dogs pretreated with 0.2 mg\/kg atropine, RL increased from 1.5 +\/- 0.31 to 18 +\/- 5.00. Atropine 0.4 and 1.0 mg\/kg did not result in increased protection. Although 0.2 mg\/kg atropine markedly inhibited the airway responses to both inhaled citric acid and methacholine, it only slightly prevented antigen-induced airway constriction. We conclude that in BG dogs, cholinergic pathways elicit bronchomotor responses to irritants but that the major component of antigen-induced bronchoconstriction is not cholinergically mediated. <\/jats:p>","DOI":"10.1152\/jappl.1981.50.4.761","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T07:03:44Z","timestamp":1514185424000},"page":"761-765","source":"Crossref","is-referenced-by-count":13,"title":["Basenji-Greyhound dog model of asthma: influence of atropine on antigen-induced bronchoconstriction"],"prefix":"10.1152","volume":"50","author":[{"given":"C. A.","family":"Hirshman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Downes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1981.50.4.761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:13:45Z","timestamp":1568009625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1981.50.4.761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,4,1]]}},"alternative-id":["10.1152\/jappl.1981.50.4.761"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1981.50.4.761","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4,1]]}}}