{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:10:29Z","timestamp":1771629029556,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1981,11,1]]},"abstract":"<jats:p> To determine whether the carotid chemoreceptors or hyperpnea are required for arousal from sleep by hypoxia, 14 sleep-deprived cats were studied during slow-wave (SWS) and rapid-eye-movement (REM) sleep. Rapid hypoxia was produced by inhalation of 5% O2 in N2 or 6% CO in 40% O2 by intact cats and 5% O2 in N2 after carotid body denervation. Preliminary studies identified a period of SWS unassociated with spontaneous arousals. In 69 studies during SWS unassociated with spontaneous arousals, arterial O2 saturation (SaO2) values at arousal were: 47.1 +\/- 1.5% (mean +\/- SE) (5% O2, intact); 48.9 +\/- 1.4% (6% CO, intact); and 49.9 +\/- 2.0% (5% O2, denervated). During SWS associated with spontaneous arousals, SaO2 values at arousal were 71.6 +\/- 1.8% (5% O2, intact). Arousal from REM occurred at significantly lower values: 31.7 +\/- 3.9% (6% CO, intact) and 43.5 +\/- 2.3% (5% O2, intact). During both SWS and REM, inhalation of 5% O2 by intact animals caused a substantial increase in ventilation while 6% CO did not. We conclude that more severe hypoxia is required for arousal from SWS when studies are done in a period unassociated with spontaneous arousals than from SWS associated with spontaneous arousals. Hypoxic arousal does not appear to require activation of the carotid bodies or hyperpnea. <\/jats:p>","DOI":"10.1152\/jappl.1981.51.5.1294","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T07:26:36Z","timestamp":1514186796000},"page":"1294-1299","source":"Crossref","is-referenced-by-count":21,"title":["Hypoxic arousal in intact and carotid chemodenervated sleeping cats"],"prefix":"10.1152","volume":"51","author":[{"given":"J. A.","family":"Neubauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. V.","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. H.","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1981.51.5.1294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:31:30Z","timestamp":1568010690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1981.51.5.1294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981,11,1]]}},"alternative-id":["10.1152\/jappl.1981.51.5.1294"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1981.51.5.1294","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,11,1]]}}}