{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:40:56Z","timestamp":1757702456824},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1982,12,1]]},"abstract":"<jats:p> Cerebral interstitial fluid (ISF) pH of ventral medulla or thalamus, cisternal cerebrospinal fluid (CSF) pH, and arterial blood pH, PCO2, and [HCO-3] were measured in chloralose-urethan-anesthetized, gallamine-paralyzed New Zealand White rabbits during 30-min episodes of either HCl or NaHCO3 intravenous infusions. ISF pH was measured continuously with glass microelectrodes (1- to 2-microns tip diameter). Cisternal CSF pH was measured continuously with an indwelling pH probe (1-mm tip diameter). Both ventral medullary and thalamic ISF [H+] changed significantly, whereas arterial PCO2 remained constant. CSF [H+] did not change. We conclude from these data that 1) changes in blood acid-base conditions are rapidly reflected in cerebral ISF and 2) transient differences in [H+] and [HCO-3] can exist between cerebral ISF and CSF. <\/jats:p>","DOI":"10.1152\/jappl.1982.53.6.1551","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T05:18:15Z","timestamp":1514179095000},"page":"1551-1555","source":"Crossref","is-referenced-by-count":10,"title":["Cerebral interstitial fluid acid-base status follows arterial acid-base perturbations"],"prefix":"10.1152","volume":"53","author":[{"given":"D. G.","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. F.","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1982.53.6.1551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:38:02Z","timestamp":1568007482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1982.53.6.1551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,12,1]]}},"alternative-id":["10.1152\/jappl.1982.53.6.1551"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1982.53.6.1551","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,12,1]]}}}