{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:39:05Z","timestamp":1771645145057,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1983,6,1]]},"abstract":"<jats:p> Discrepancies exist between reported effects of histamine on the alpha-adrenergic responsiveness of the canine trachealis muscle. Therefore, using an in situ preparation described recently (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 84\u201394, 1980), we tested the effects of histamine and other agents on alpha-adrenergic responses in the trachealis muscle of 34 anesthetized dogs. Under basal conditions, maximum alpha-adrenergic responses were small [3 +\/- 1 (SE) g\/cm] compared with those induced by a supramaximal parasympathetic stimulus (45 +\/- 3 g\/cm). After exposure of the muscle to histamine, responsiveness increased markedly to alpha-adrenergic stimuli, which included tracheal arterial injections of norepinephrine and phenylephrine or electrical stimulation of sympathetic nerves. Augmented alpha-adrenergic responsiveness persisted for 20 min after the end of contractions induced by histamine. Serotonin and long-acting, but not short-acting, cholinergic agonists also potentiated alpha-adrenergic responsiveness. We concluded that exposure of the trachealis muscle in living dogs to a variety of constrictor stimuli potently augmented its alpha-adrenergic responsiveness. <\/jats:p>","DOI":"10.1152\/jappl.1983.54.6.1558","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T05:07:02Z","timestamp":1514178422000},"page":"1558-1566","source":"Crossref","is-referenced-by-count":12,"title":["Augmentation of alpha-adrenergic contractions in the trachealis muscle of living dogs"],"prefix":"10.1152","volume":"54","author":[{"given":"J. K.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1983.54.6.1558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:31:52Z","timestamp":1568007112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1983.54.6.1558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6,1]]}},"alternative-id":["10.1152\/jappl.1983.54.6.1558"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1983.54.6.1558","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6,1]]}}}