{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:14:50Z","timestamp":1790100890162,"version":"4.0.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1984,8,1]]},"abstract":"<jats:p> For the first time in the rat, we described the effects of exercise on arterial acid-base status and examined the role of chemical stimuli as determinants of the hyperventilatory response in this species. O2 consumption (VO2), CO2 production (VCO2), arterial blood gases, arterial lactate concentration ([LA-]a), and rectal temperature (Tre) were measured in non-trained male rats at rest and during 10 min of treadmill exercise at various intensities. During mild exercise (2.5-fold increase in VCO2), PaCO2 fell 5.5 +\/- 0.6 Torr, and despite a small but significant increase in [LA-]a, respiratory alkalosis prevailed [change in arterial pH (delta pHa) = 0.034 +\/- 0.006]. Arterial PO2 (PaO2) increased 4.1 +\/- 1.5 Torr and Tre increased 0.6 +\/- 0.1 degrees C. A progressive hyperventilation occurred from mild to heavy exercise. This response was not attributable to arterial hypoxemia or acidosis and it was not affected by preventing the exercise-induced increase in body temperature. During maximal exercise, VO2 increased 3.4-fold (72 +\/- 1.50 ml X kg-1 X min-1) and VCO2 increased 4.5-fold (74 +\/- 1.90 ml X kg-1 X min-1), resulting in a 9-fold increase in [LA-]a and a severe metabolic acidosis (pHa 7.31 +\/- 0.02). A marked hyperventilation [arterial PCO2 (PaCO2) 28.5 +\/- 1.4 Torr] resulted in partial compensation of pHa, but almost all of this hyperventilation occurred before the onset of metabolic acidosis, [i.e., at less than 65% maximum VO2 (VO2max)], and the increased [H+]a with further elevations in VO2 produced no further hypocapnia.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/jappl.1984.57.2.396","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T08:10:00Z","timestamp":1513843800000},"page":"396-402","source":"Crossref","is-referenced-by-count":47,"title":["Arterial blood acid-base regulation during exercise in rats"],"prefix":"10.1152","volume":"57","author":[{"given":"R. F.","family":"Fregosi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1984.57.2.396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T11:18:12Z","timestamp":1567941492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1984.57.2.396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,8,1]]}},"alternative-id":["10.1152\/jappl.1984.57.2.396"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1984.57.2.396","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,8,1]]}}}