{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:53:41Z","timestamp":1761490421272},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1985,9,1]]},"abstract":"<jats:p> To study the effect of endorphins on metabolic rate and on the relationship between O2 consumption (VO2) and ventilation, we administered enkephalin analogues (relatively selective delta-receptor agonists) and a morphiceptin analogue (a highly selective mu-receptor agonist) intracisternally in nine unanesthetized chronically instrumented adult dogs. Both delta- and mu-agonists decreased VO2 by 40\u201360%. delta-Agonists induced a dose-dependent decrease in mean instantaneous minute ventilation (VT\/TT) associated with periodic breathing. The decrease in VT\/TT started and resolved prior to the decrease and returned to baseline of VO2, respectively. In contrast, the mu-agonists induced an increase in VT\/TT associated with rapid shallow breathing. Arterial PCO2 increased and arterial PO2 decreased after both delta- and mu-agonists. Low doses of intracisternal naloxone (0.002\u20132.0 micrograms\/kg) reversed the opioid effect on VT\/TT but not on VO2; higher doses of naloxone (5\u201325 micrograms\/kg) reversed both. Naloxone administered alone had no effect on VT\/TT or VO2. These data suggest that 1) both delta- and mu-agonists induce alveolar hypoventilation despite a decrease in VO2, 2) this hypoventilation results from a decrease in VT\/TT after delta-agonists but an increase in dead space ventilation after mu-agonists, and 3) endorphins do not modulate ventilation and metabolic rate tonically, but we speculate that they may do so in response to stressful stimulation. <\/jats:p>","DOI":"10.1152\/jappl.1985.59.3.959","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T13:40:30Z","timestamp":1513863630000},"page":"959-968","source":"Crossref","is-referenced-by-count":19,"title":["Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists"],"prefix":"10.1152","volume":"59","author":[{"given":"J. I.","family":"Schaeffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. G.","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1985.59.3.959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:25:12Z","timestamp":1567956312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1985.59.3.959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,9,1]]}},"alternative-id":["10.1152\/jappl.1985.59.3.959"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1985.59.3.959","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9,1]]}}}